Interactions for 2J7Z — Binding Partner: CXCL12
Structure details
- PDB ID: 2J7Z open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: X-ray
- Resolution: 1.95 Å
- Date: Oct. 23, 2006
- Reference: 10.1002/PROT.21350 open_in_new
- State: Dimer
- Chemokine Chain: A
- Partner Chain: B
Chemokine diagram
Interactions for this Binding Partner
Download list as CSV
| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Val 23 | B1.2 | B1 | ASN 30 | B | HBAcceptor |
| Val 23 | B1.2 | B1 | ASN 30 | B | VdWContact |
| Lys 24 | B1.3 | B1 | ASN 30 | B | HBAcceptor |
| Lys 24 | B1.3 | B1 | ASN 30 | B | VdWContact |
| His 25 | B1.4 | B1 | LEU 29 | B | Hydrophobic |
| His 25 | B1.4 | B1 | LYS 27 | B | Hydrophobic |
| Leu 26 | B1.5 | B1 | ILE 28 | B | HBAcceptor |
| Leu 26 | B1.5 | B1 | ILE 28 | B | HBDonor |
| Leu 26 | B1.5 | B1 | ILE 28 | B | VdWContact |
| Leu 26 | B1.5 | B1 | LYS 27 | B | VdWContact |
| Lys 27 | B1.6 | B1 | LEU 26 | B | VdWContact |
| Lys 27 | B1.6 | B1 | HIS 25 | B | Hydrophobic |
| Lys 27 | B1.6 | B1 | LYS 27 | B | Hydrophobic |
| Ile 28 | B1.7 | B1 | HIS 25 | B | VdWContact |
| Ile 28 | B1.7 | B1 | LEU 26 | B | HBAcceptor |
| Ile 28 | B1.7 | B1 | LEU 26 | B | HBDonor |
| Ile 28 | B1.7 | B1 | LEU 26 | B | VdWContact |
| Ile 28 | B1.7 | B1 | LEU 62 | B | Hydrophobic |
| Ile 28 | B1.7 | B1 | ALA 65 | B | Hydrophobic |
| Ile 28 | B1.7 | B1 | TYR 61 | B | Hydrophobic |
| Ile 28 | B1.7 | B1 | TYR 61 | B | HBAcceptor |
| Ile 28 | B1.7 | B1 | TYR 61 | B | VdWContact |
| Ile 28 | B1.7 | B1 | ILE 28 | B | Hydrophobic |
| Leu 29 | b1b2.4 | 30s-loop | HIS 25 | B | Hydrophobic |
| Asn 30 | b1b2.7 | 30s-loop | LYS 24 | B | HBDonor |
| Asn 30 | b1b2.7 | 30s-loop | LYS 24 | B | VdWContact |
| Asn 30 | b1b2.7 | 30s-loop | VAL 23 | B | HBDonor |
| Asn 30 | b1b2.7 | 30s-loop | VAL 23 | B | VdWContact |
| Asn 30 | b1b2.7 | 30s-loop | TYR 61 | B | Hydrophobic |
| Asn 30 | b1b2.7 | 30s-loop | TYR 61 | B | VdWContact |
| Gln 37 | B2.1 | B2 | ALA 65 | B | Hydrophobic |
| Gln 37 | B2.1 | B2 | ALA 65 | B | VdWContact |
| Ile 38 | B2.2 | B2 | LEU 66 | B | Hydrophobic |
| Ile 58 | H.3 | Helix | LEU 66 | B | Hydrophobic |
| Gln 59 | H.4 | Helix | LEU 66 | B | Hydrophobic |
| Gln 59 | H.4 | Helix | LYS 68 | B | VdWContact |
| Tyr 61 | H.6 | Helix | ASN 30 | B | Hydrophobic |
| Tyr 61 | H.6 | Helix | ASN 30 | B | VdWContact |
| Tyr 61 | H.6 | Helix | ILE 28 | B | Hydrophobic |
| Tyr 61 | H.6 | Helix | ILE 28 | B | HBDonor |
| Tyr 61 | H.6 | Helix | ILE 28 | B | VdWContact |
| Leu 62 | H.7 | Helix | LEU 66 | B | Hydrophobic |
| Leu 62 | H.7 | Helix | LEU 62 | B | Hydrophobic |
| Leu 62 | H.7 | Helix | ILE 28 | B | Hydrophobic |
| Ala 65 | H.10 | Helix | GLN 37 | B | Hydrophobic |
| Ala 65 | H.10 | Helix | GLN 37 | B | VdWContact |
| Ala 65 | H.10 | Helix | ILE 38 | B | Hydrophobic |
| Ala 65 | H.10 | Helix | ILE 28 | B | Hydrophobic |
| Leu 66 | CT.1 | C-term | ILE 38 | B | Hydrophobic |
| Leu 66 | CT.1 | C-term | LEU 62 | B | Hydrophobic |
| Leu 66 | CT.1 | C-term | LEU 62 | B | VdWContact |
| Leu 66 | CT.1 | C-term | ILE 58 | B | Hydrophobic |
| Leu 66 | CT.1 | C-term | LYS 54 | B | HBAcceptor |
| Leu 66 | CT.1 | C-term | LYS 54 | B | VdWContact |
| Lys 68 | CT.3 | C-term | GLN 37 | B | VdWContact |
| Lys 68 | CT.3 | C-term | PRO 32 | B | HBDonor |
| Lys 68 | CT.3 | C-term | PRO 32 | B | VdWContact |
| Lys 68 | CT.3 | C-term | LYS 54 | B | HBAcceptor |
| Lys 68 | CT.3 | C-term | LYS 54 | B | Anionic |
| Lys 68 | CT.3 | C-term | LYS 54 | B | VdWContact |
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