Interactions for 2K05 — Binding Partner: CXCR4 N-terminal peptide


Structure details

  • Chemokine Chain: A
  • Partner Chain: B
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Chemokine diagram

L N T P N C A C 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term K P V S L S Y R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K C L N K

Interactions for this Binding Partner

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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Leu 5 NTc.Cm4 N-term ASP 110 B VdWContact
Leu 5 NTc.Cm4 N-term THR 108 B Hydrophobic
Leu 5 NTc.Cm4 N-term THR 108 B VdWContact
Ser 6 NTc.Cm3 N-term ASP 110 B HBDonor
Ser 6 NTc.Cm3 N-term ASP 110 B VdWContact
Arg 8 NTc.Cm1 N-term ASP 110 B HBDonor
Arg 8 NTc.Cm1 N-term ASP 110 B Cationic
Arg 8 NTc.Cm1 N-term ASP 110 B VdWContact
Pro 10 CX.4 CX TYS 112 B Hydrophobic
Pro 10 CX.4 CX TYS 112 B VdWContact
Phe 13 cxb1.2 N-loop SER 118 B VdWContact
Phe 14 cxb1.5 N-loop SER 123 B HBAcceptor
Phe 14 cxb1.5 N-loop SER 123 B VdWContact
Glu 15 cxb1.6 N-loop SER 123 B HBAcceptor
Glu 15 cxb1.6 N-loop SER 123 B VdWContact
Glu 15 cxb1.6 N-loop ASP 122 B HBAcceptor
Glu 15 cxb1.6 N-loop ASP 122 B VdWContact
Glu 15 cxb1.6 N-loop TYS 121 B Hydrophobic
Glu 15 cxb1.6 N-loop TYS 121 B HBAcceptor
Glu 15 cxb1.6 N-loop TYS 121 B VdWContact
Glu 15 cxb1.6 N-loop ASP 120 B HBAcceptor
Glu 15 cxb1.6 N-loop ASP 120 B VdWContact
Ser 16 cxb1.8 N-loop SER 123 B VdWContact
His 17 cxb1.10 N-loop LYS 125 B Hydrophobic
His 17 cxb1.10 N-loop ASP 122 B Hydrophobic
His 17 cxb1.10 N-loop ASP 122 B VdWContact
His 17 cxb1.10 N-loop TYS 121 B VdWContact
Val 18 cxb1.11 N-loop TYS 121 B Hydrophobic
Asn 22 B1.1 B1 TYS 121 B HBDonor
Asn 22 B1.1 B1 TYS 121 B VdWContact
Lys 27 B1.6 B1 TYS 112 B Hydrophobic
Lys 27 B1.6 B1 TYS 112 B VdWContact
Leu 29 b1b2.4 30s-loop SER 109 B VdWContact
Leu 29 b1b2.4 30s-loop TYS 112 B Hydrophobic
Asn 30 b1b2.7 30s-loop ILE 106 B Hydrophobic
Asn 30 b1b2.7 30s-loop ILE 106 B VdWContact
Asn 30 b1b2.7 30s-loop SER 109 B HBAcceptor
Asn 30 b1b2.7 30s-loop SER 109 B VdWContact
Asn 30 b1b2.7 30s-loop TYS 107 B Hydrophobic
Asn 30 b1b2.7 30s-loop TYS 107 B HBDonor
Asn 30 b1b2.7 30s-loop TYS 107 B VdWContact
Thr 31 b1b2.8 30s-loop ILE 106 B VdWContact
Pro 32 b1b2.9 30s-loop ILE 106 B Hydrophobic
Val 39 B2.3 B2 TYS 112 B VdWContact
Arg 41 B2.5 B2 GLU 114 B HBDonor
Arg 41 B2.5 B2 GLU 114 B Cationic
Arg 41 B2.5 B2 GLU 114 B VdWContact
Asn 46 b2b3.11 40s-loop TYS 121 B HBDonor
Asn 46 b2b3.11 40s-loop TYS 121 B VdWContact
Arg 47 b2b3.12 40s-loop TYS 121 B Cationic
Arg 47 b2b3.12 40s-loop TYS 121 B VdWContact
Arg 47 b2b3.12 40s-loop ASP 120 B HBDonor
Arg 47 b2b3.12 40s-loop ASP 120 B Cationic
Arg 47 b2b3.12 40s-loop ASP 120 B VdWContact
Gln 48 B3.1 B3 GLU 115 B HBAcceptor
Gln 48 B3.1 B3 GLU 115 B HBDonor
Gln 48 B3.1 B3 GLU 115 B VdWContact
Gln 48 B3.1 B3 GLU 114 B VdWContact
Val 49 B3.2 B3 TYS 121 B Hydrophobic
Lys 54 b3h.3 50s-loop PRO 127 B Hydrophobic
Lys 54 b3h.3 50s-loop PRO 127 B VdWContact
Lys 54 b3h.3 50s-loop LYS 125 B HBDonor
Lys 54 b3h.3 50s-loop LYS 125 B VdWContact
Lys 56 H.1 Helix GLU 132 B Hydrophobic
Lys 56 H.1 Helix GLU 132 B HBDonor
Lys 56 H.1 Helix GLU 132 B Cationic
Lys 56 H.1 Helix GLU 132 B VdWContact
Gln 59 H.4 Helix PRO 127 B Hydrophobic
Glu 63 H.8 Helix ARG 130 B HBAcceptor
Glu 63 H.8 Helix ARG 130 B Anionic
Glu 63 H.8 Helix ARG 130 B VdWContact

Interaction pattern search
(0.00 = no similarity, 1.00 = identical)