CCL3_HUMAN

  • Alternate name(s): C-C motif chemokine 3
  • Organism: Homo sapiens
  • UniProt ID: P10147 open_in_new


Wild type sequence

Residue N-term   CX   N-loop   B1   30s-loop   B2   40s-loop   B3   50s-loop   Helix   C-term  
  NTc.Cm33 NTc.Cm32 NTc.Cm31 NTc.Cm30 NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1   CX.1 CX.5   cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.7 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16   B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7   b1b2.4 b1b2.6 b1b2.9 b1b2.10 b1b2.12 b1b2.13 b1b2.14 b1b2.16   B2.1 B2.2 B2.3 B2.4 B2.5 B2.6   b2b3.2 b2b3.4 b2b3.11 b2b3.12   B3.1 B3.2 B3.3 B3.4   b3h.1 b3h.2 b3h.3 b3h.4   H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10   CT.1 CT.2 CT.3 CT.4  
Wild Type M Q V S T A A L A V L L C T M A L C N Q F S A S L A A D T P T A   C C   F S Y T S R Q I P Q N   F I A D Y F E   T S S Q C S K P   G V I F L T   K R S R   Q V C A   D P S E   E W V Q K Y V S D L   E L S A  

Snake Plot

T S S Q C S K P 30s-loop K R S R 40s-loop D P S E 50s-loopC-term M Q V S T A A L A V L L C T M A L C N Q F S A S L A A D T P T A C C F S Y T S R Q I P Q N N-term E F Y D A I F G V I F L T A C V Q E W V Q K Y V S D L E L S A
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 



List of structures

PDB Method Resolution State Publication date Reference
1B50 - A,B Nmr None Dimer 1999-07-22 10.1074/JBC.274.23.16077 open_in_new
1B53 - A,B Nmr None Dimer 1999-07-22 10.1074/JBC.274.23.16077 open_in_new
2X69 - A,B,C,D,E X-ray 2.65 Oligomer 2010-11-03 10.1038/EMBOJ.2010.256 open_in_new
3FPU - B X-ray 1.76 Monomer 2010-01-12 10.1371/JOURNAL.PONE.0008514 open_in_new
2X6G - M,B,C,E,F,H,I,L,O,A,N,P,R,G,J,K,Q,D X-ray 2.15 Oligomer 2010-11-03 10.1038/EMBOJ.2010.256 open_in_new
3H44 - C,D X-ray 3.0 Monomer 2010-04-14 -
3KBX - A,B,C,D,E X-ray 2.65 Oligomer 2010-10-27 -
4RA8 - A,B,C,D,E X-ray 2.6 Oligomer 2014-09-24 10.1016/J.JMB.2015.01.012 open_in_new
4ZKB - B X-ray 2.9 Monomer 2015-07-08 10.1016/J.STR.2015.04.023 open_in_new
5COR - B,C,E,F,H,I,A,G,J,D X-ray 2.55 Oligomer 2016-04-13 10.1073/PNAS.1523981113 open_in_new
5D65 - B,C,E,A,D X-ray 3.1 Oligomer 2016-04-20 10.1073/PNAS.1523981113 open_in_new
7F1Q - R Cryo-em 2.9 Monomer 2021-07-14 10.1038/S41467-021-24438-5 open_in_new
7F1T - A X-ray 2.6 Monomer 2021-07-14 10.1038/S41467-021-24438-5 open_in_new

Sequence alignment from structures

Position NTc.Cm33 NTc.Cm32 NTc.Cm31 NTc.Cm30 NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1 CX.1 CX.5 cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.7 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16 B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7 b1b2.4 b1b2.6 b1b2.9 b1b2.10 b1b2.12 b1b2.13 b1b2.14 b1b2.16 B2.1 B2.2 B2.3 B2.4 B2.5 B2.6 b2b3.2 b2b3.4 b2b3.11 b2b3.12 B3.1 B3.2 B3.3 B3.4 b3h.1 b3h.2 b3h.3 b3h.4 H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10 CT.1 CT.2 CT.3 CT.4
Canonical Sequence M Q V S T A A L A V L L C T M A L C N Q F S A S L A A D T P T A C C F S Y T S R Q I P Q N F I A D Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S A
1B50 - A,B - - - - - - - - - - - - - - - - - - - - - - - S L A A D T P T A C C F S Y T S R Q I P Q N F I A A Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S A
1B53 - A,B - - - - - - - - - - - - - - - - - - - - - - - S L A A D T P T A C C F S - T S R Q I P Q N F I A A Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S A
2X69 - A,B,C,D,E - - - - - - - - - - - - - - - - - - - - - - - - - A A D T P T A C C F S Y T S R Q I P Q N F I A D Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S -
3FPU - B - - - - - - - - - - - - - - - - - - - - - - - S L A A D T P T T C C F S Y T S R Q I P Q N F I A D Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E - - -
2X6G - M,B,C,E,F,H,I,L,O,A,N,P,R,G,J,K,Q,D - - - - - - - - - - - - - - - - - - - - - - - - L A A D T P T A C C F S Y T S R Q I P Q N F I A A Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S A
3H44 - C,D A S L A K R S R Q V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A S L A S R Q V
3KBX - A,B,C,D,E - - - - - - - - - - - - - - - - - - - - - - - - - A A D T P T A C C F S Y T S R Q I P Q N F I A D Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y - - S D L E L S
4RA8 - A,B,C,D,E - - - - - - - - - - - - - - - - - - - - - - A S L A A D T A T A C C F S Y T S R Q I P Q N F I A D Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S -
4ZKB - B - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T A C C F S Y T S R Q I P - - - - - D Y F E T S S Q C S K P G V I F L T - - - R Q V C A D P S E E W V Q K Y V S D - - - - -
5COR - B,C,E,F,H,I,A,G,J,D - - - - - - - - - - - - - - - - - - - - - - A S L A A D T P T A C C F S Y T S R Q I P Q N F I A D Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S A
5D65 - B,C,E,A,D - - - - - - - - - - - - - - - - - - - - - - A S L A A D T P T A C C F S Y T S R Q I P Q N F I A D Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S -
7F1Q - R - - - - - - - - - - - - - - - - - - - - - - - S L A A D T P T A C C F S Y C S R Q I P Q N F I A D Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S A
7F1T - A - - - - - - - - - - - - - - - - - - - - - - - - - A A D T P T A C C F S Y C S R Q I P Q N F I A D Y F E T S S Q C S K P G V I F L T K R S R Q V C A D P S E E W V Q K Y V S D L E L S A