Interactions for 2NWG — Binding Partner: CXCL12


Structure details

  • Chemokine Chain: B
  • Partner Chain: A
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Chemokine diagram

L N T P N C A L 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term S L S Y R C P C R F F E S H I A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K A L N

Interactions for this Binding Partner

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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Val 23 B1.2 B1 ASN 30 A HBAcceptor
Val 23 B1.2 B1 ASN 30 A VdWContact
Lys 24 B1.3 B1 ASN 30 A HBAcceptor
Lys 24 B1.3 B1 ASN 30 A VdWContact
His 25 B1.4 B1 LYS 27 A Hydrophobic
His 25 B1.4 B1 LYS 27 A VdWContact
His 25 B1.4 B1 LEU 29 A Hydrophobic
Leu 26 B1.5 B1 ILE 28 A Hydrophobic
Leu 26 B1.5 B1 ILE 28 A HBAcceptor
Leu 26 B1.5 B1 ILE 28 A HBDonor
Leu 26 B1.5 B1 ILE 28 A VdWContact
Leu 26 B1.5 B1 LYS 27 A VdWContact
Lys 27 B1.6 B1 LEU 26 A VdWContact
Lys 27 B1.6 B1 HIS 25 A Hydrophobic
Lys 27 B1.6 B1 HIS 25 A CationPi
Lys 27 B1.6 B1 LYS 27 A Hydrophobic
Ile 28 B1.7 B1 ILE 28 A Hydrophobic
Ile 28 B1.7 B1 ALA 65 A Hydrophobic
Ile 28 B1.7 B1 TYR 61 A Hydrophobic
Ile 28 B1.7 B1 TYR 61 A HBAcceptor
Ile 28 B1.7 B1 TYR 61 A VdWContact
Ile 28 B1.7 B1 LEU 26 A HBAcceptor
Ile 28 B1.7 B1 LEU 26 A HBDonor
Ile 28 B1.7 B1 LEU 26 A VdWContact
Ile 28 B1.7 B1 HIS 25 A VdWContact
Ile 28 B1.7 B1 LEU 62 A Hydrophobic
Ile 28 B1.7 B1 LEU 62 A VdWContact
Leu 29 b1b2.4 30s-loop TYR 61 A VdWContact
Leu 29 b1b2.4 30s-loop HIS 25 A Hydrophobic
Asn 30 b1b2.7 30s-loop ARG 20 A HBAcceptor
Asn 30 b1b2.7 30s-loop ARG 20 A VdWContact
Asn 30 b1b2.7 30s-loop TYR 61 A Hydrophobic
Asn 30 b1b2.7 30s-loop TYR 61 A VdWContact
Asn 30 b1b2.7 30s-loop VAL 23 A HBDonor
Asn 30 b1b2.7 30s-loop VAL 23 A VdWContact
Asn 30 b1b2.7 30s-loop LYS 24 A HBDonor
Asn 30 b1b2.7 30s-loop LYS 24 A VdWContact
Gln 37 B2.1 B2 ALA 65 A Hydrophobic
Gln 37 B2.1 B2 ALA 65 A VdWContact
Ile 38 B2.2 B2 ALA 65 A Hydrophobic
Ile 38 B2.2 B2 ALA 65 A VdWContact
Ile 38 B2.2 B2 LEU 66 A Hydrophobic
Lys 54 b3h.3 50s-loop LEU 66 A HBDonor
Lys 54 b3h.3 50s-loop LEU 66 A VdWContact
Lys 54 b3h.3 50s-loop ASN 67 A Cationic
Lys 54 b3h.3 50s-loop ASN 67 A VdWContact
Ile 58 H.3 Helix LEU 66 A Hydrophobic
Ile 58 H.3 Helix LEU 66 A VdWContact
Gln 59 H.4 Helix LEU 66 A Hydrophobic
Tyr 61 H.6 Helix ILE 28 A Hydrophobic
Tyr 61 H.6 Helix ILE 28 A HBDonor
Tyr 61 H.6 Helix ILE 28 A VdWContact
Tyr 61 H.6 Helix ASN 30 A Hydrophobic
Tyr 61 H.6 Helix ASN 30 A VdWContact
Leu 62 H.7 Helix ILE 28 A Hydrophobic
Leu 62 H.7 Helix ILE 28 A VdWContact
Leu 62 H.7 Helix LEU 66 A Hydrophobic
Leu 62 H.7 Helix LEU 62 A Hydrophobic
Ala 65 H.10 Helix ILE 28 A Hydrophobic
Ala 65 H.10 Helix ILE 28 A VdWContact
Ala 65 H.10 Helix ILE 38 A Hydrophobic
Ala 65 H.10 Helix GLN 37 A Hydrophobic
Ala 65 H.10 Helix GLN 37 A VdWContact
Leu 66 CT.1 C-term ILE 38 A Hydrophobic
Leu 66 CT.1 C-term LEU 62 A Hydrophobic
Leu 66 CT.1 C-term LEU 62 A VdWContact
Leu 66 CT.1 C-term GLN 59 A Hydrophobic
Leu 66 CT.1 C-term ILE 58 A Hydrophobic
Asn 67 CT.2 C-term LYS 54 A HBAcceptor
Asn 67 CT.2 C-term LYS 54 A Anionic
Asn 67 CT.2 C-term LYS 54 A VdWContact

Interaction pattern search
(0.00 = no similarity, 1.00 = identical)