Interactions

4DN4 | CCL2_HUMAN — CNTO888

Residue contacts: 46
SUMMARY
Protein
CCL2_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P13500 View on UniProt
PDB ID
4DN4 View on PDB
Method
X-ray
Resolution
2.8 Å
Date
Oct. 3, 2012
Reference
10.1016/J.MOLIMM.2012.03.022 Open DOI
State
Monomer
Chain information
Chemokine chain
M
Partner chain
H,L
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Arg 18 cxb1.8 N-loop GLU 105 H HBDonor
Arg 18 cxb1.8 N-loop GLU 105 H Cationic
Arg 18 cxb1.8 N-loop GLU 105 H VdWContact
Arg 18 cxb1.8 N-loop ASP 51 L HBDonor
Arg 18 cxb1.8 N-loop ASP 51 L Cationic
Arg 18 cxb1.8 N-loop ASP 51 L VdWContact
Arg 18 cxb1.8 N-loop TYR 50 L VdWContact
Arg 18 cxb1.8 N-loop TYR 103 H Hydrophobic
Arg 18 cxb1.8 N-loop TYR 103 H HBAcceptor
Arg 18 cxb1.8 N-loop TYR 103 H CationPi
Arg 18 cxb1.8 N-loop TYR 103 H VdWContact
Lys 19 cxb1.10 N-loop ASP 31 L HBDonor
Lys 19 cxb1.10 N-loop ASP 31 L Cationic
Lys 19 cxb1.10 N-loop ASP 31 L VdWContact
Ile 20 cxb1.11 N-loop ILE 102 H Hydrophobic
Ile 20 cxb1.11 N-loop TYR 103 H Hydrophobic
Ser 21 cxb1.14 N-loop TYR 33 L HBDonor
Ser 21 cxb1.14 N-loop TYR 33 L VdWContact
Ser 21 cxb1.14 N-loop ASP 31 L HBDonor
Ser 21 cxb1.14 N-loop ASP 31 L VdWContact
Arg 24 B1.1 B1 TYR 92 L HBDonor
Arg 24 B1.1 B1 TYR 92 L VdWContact
Arg 24 B1.1 B1 TYR 33 L Hydrophobic
Arg 24 B1.1 B1 ILE 102 H Hydrophobic
Arg 24 B1.1 B1 ILE 102 H VdWContact
Arg 24 B1.1 B1 LEU 95 L VdWContact
Arg 24 B1.1 B1 GLY 101 H HBDonor
Arg 24 B1.1 B1 GLY 101 H VdWContact
Arg 24 B1.1 B1 TYR 103 H HBDonor
Arg 24 B1.1 B1 TYR 103 H VdWContact
Arg 24 B1.1 B1 ILE 93 L HBDonor
Arg 24 B1.1 B1 ILE 93 L VdWContact
Thr 45 B2.6 B2 ILE 102 H Hydrophobic
Thr 45 B2.6 B2 ILE 102 H VdWContact
Ile 46 b2b3.2 40s-loop PHE 55 H VdWContact
Val 47 b2b3.4 40s-loop ILE 54 H Hydrophobic
Val 47 b2b3.4 40s-loop PHE 55 H Hydrophobic
Val 47 b2b3.4 40s-loop ILE 52 H Hydrophobic
Val 47 b2b3.4 40s-loop GLY 101 H VdWContact
Ala 48 b2b3.11 40s-loop ILE 54 H Hydrophobic
Lys 49 b2b3.12 40s-loop SER 31 H HBDonor
Lys 49 b2b3.12 40s-loop SER 31 H VdWContact
Lys 49 b2b3.12 40s-loop ASP 100 H HBDonor
Lys 49 b2b3.12 40s-loop ASP 100 H Cationic
Lys 49 b2b3.12 40s-loop ASP 100 H VdWContact
Ile 51 B3.2 B3 ILE 102 H Hydrophobic
CHEMOKINE DIAGRAM
I T S S K C P K E 30s-loop I V A K 40s-loop D P K Q 50s-loopC-term V T C C Y N F T N R K I S V Q N-term R R Y S A L R A V I F K T A C I E K W V Q D S M D H L D K
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical