Interactions

4LMQ | CXCL12_HUMAN — hu30D8 Fab

Residue contacts: 43
SUMMARY
Protein
CXCL12_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P48061 View on UniProt
PDB ID
4LMQ View on PDB
Method
X-ray
Resolution
2.77 Å
Date
Aug. 14, 2013
Reference
10.1158/1078-0432.CCR-13-0943 Open DOI
State
Dimer
Chain information
Chemokine chain
F
Partner chain
I,E
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Glu 15 cxb1.6 N-loop ASN 99 E HBAcceptor
Glu 15 cxb1.6 N-loop ASN 99 E VdWContact
His 17 cxb1.10 N-loop TYR 31 I Hydrophobic
His 17 cxb1.10 N-loop TYR 31 I PiStacking
His 17 cxb1.10 N-loop ASN 50 I HBAcceptor
His 17 cxb1.10 N-loop ASN 50 I VdWContact
Val 18 cxb1.11 N-loop ASN 99 E Hydrophobic
Val 18 cxb1.11 N-loop ASN 99 E VdWContact
Ala 19 cxb1.14 N-loop TYR 100 E HBDonor
Ala 19 cxb1.14 N-loop TYR 100 E VdWContact
Ala 19 cxb1.14 N-loop TYR 91 I Hydrophobic
Ala 19 cxb1.14 N-loop TRP 92 I Hydrophobic
Ala 19 cxb1.14 N-loop TRP 92 I VdWContact
Ala 19 cxb1.14 N-loop SER 32 I VdWContact
Arg 20 cxb1.15 N-loop TRP 92 I Hydrophobic
Arg 20 cxb1.15 N-loop TRP 92 I VdWContact
Ala 21 cxb1.16 N-loop PHE 96 I Hydrophobic
Ala 21 cxb1.16 N-loop ASN 93 I VdWContact
Ala 21 cxb1.16 N-loop TRP 92 I HBDonor
Ala 21 cxb1.16 N-loop TRP 92 I VdWContact
Asn 22 B1.1 B1 ASN 99 E HBDonor
Asn 22 B1.1 B1 ASN 99 E VdWContact
Leu 42 B2.6 B2 ASN 99 E Hydrophobic
Lys 43 b2b3.2 40s-loop GLU 58 E HBDonor
Lys 43 b2b3.2 40s-loop GLU 58 E Cationic
Lys 43 b2b3.2 40s-loop GLU 58 E VdWContact
Lys 43 b2b3.2 40s-loop TRP 52 E Hydrophobic
Lys 43 b2b3.2 40s-loop TRP 52 E VdWContact
Asn 44 b2b3.3 40s-loop LEU 98 E HBDonor
Asn 44 b2b3.3 40s-loop LEU 98 E VdWContact
Asn 44 b2b3.3 40s-loop ASP 95 E HBDonor
Asn 44 b2b3.3 40s-loop ASP 95 E VdWContact
Asn 44 b2b3.3 40s-loop SER 33 E HBAcceptor
Asn 44 b2b3.3 40s-loop SER 33 E VdWContact
Asn 44 b2b3.3 40s-loop TRP 52 E Hydrophobic
Asn 45 b2b3.4 40s-loop ASN 99 E HBDonor
Asn 45 b2b3.4 40s-loop ASN 99 E VdWContact
Asn 45 b2b3.4 40s-loop GLY 97 E HBDonor
Asn 45 b2b3.4 40s-loop GLY 97 E VdWContact
Arg 47 b2b3.12 40s-loop ASN 99 E HBDonor
Arg 47 b2b3.12 40s-loop ASN 99 E VdWContact
Trp 57 H.2 Helix TRP 92 I Hydrophobic
Trp 57 H.2 Helix TRP 92 I VdWContact
CHEMOKINE DIAGRAM
L N T P N C A L 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K A
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical