Interactions for 4R9Y — Binding Partner: CXCL4
Structure details
- PDB ID: 4R9Y open_in_new
- Protein: CXCL4_HUMAN
- Organism: Homo sapiens
- UniProt ID: P02776 open_in_new
- Method: X-ray
- Resolution: 4.11 Å
- Date: Dec. 16, 2015
- Reference: 10.1038/NCOMMS9277 open_in_new
- State: Tetramer
- Chemokine Chain: A
- Partner Chain: B,C,D
Chemokine diagram
Interactions for this Binding Partner
Download list as CSV
| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Asp 7 | NTc.Cm3 | N-term | VAL 13 | C | VdWContact |
| Leu 8 | NTc.Cm2 | N-term | LEU 11 | C | VdWContact |
| Leu 8 | NTc.Cm2 | N-term | LYS 50 | C | VdWContact |
| Leu 8 | NTc.Cm2 | N-term | CYS 12 | C | Hydrophobic |
| Leu 8 | NTc.Cm2 | N-term | CYS 12 | C | VdWContact |
| Gln 9 | NTc.Cm1 | N-term | LEU 11 | C | HBDonor |
| Gln 9 | NTc.Cm1 | N-term | LEU 11 | C | VdWContact |
| Gln 9 | NTc.Cm1 | N-term | GLN 9 | C | VdWContact |
| Cys 10 | CX.1 | CX | GLN 9 | C | HBAcceptor |
| Leu 11 | CX.4 | CX | LEU 11 | C | Hydrophobic |
| Leu 11 | CX.4 | CX | LEU 11 | C | VdWContact |
| Leu 11 | CX.4 | CX | GLN 9 | C | VdWContact |
| Leu 11 | CX.4 | CX | LEU 8 | C | VdWContact |
| Val 13 | cxb1.1 | N-loop | GLN 9 | C | Hydrophobic |
| Val 13 | cxb1.1 | N-loop | GLN 9 | C | VdWContact |
| Val 13 | cxb1.1 | N-loop | ASP 7 | C | Hydrophobic |
| Val 13 | cxb1.1 | N-loop | ASP 7 | C | VdWContact |
| Lys 14 | cxb1.2 | N-loop | ASP 7 | C | Hydrophobic |
| Lys 14 | cxb1.2 | N-loop | ASP 7 | C | VdWContact |
| Ile 24 | B1.2 | B1 | LYS 31 | B | VdWContact |
| Thr 25 | B1.3 | B1 | LYS 31 | B | Hydrophobic |
| Thr 25 | B1.3 | B1 | LYS 31 | B | VdWContact |
| Ser 26 | B1.4 | B1 | ILE 30 | B | VdWContact |
| Ser 26 | B1.4 | B1 | VAL 29 | B | VdWContact |
| Leu 27 | B1.5 | B1 | LEU 27 | B | VdWContact |
| Glu 28 | B1.6 | B1 | GLU 28 | B | Hydrophobic |
| Val 29 | B1.7 | B1 | LEU 27 | B | HBAcceptor |
| Val 29 | B1.7 | B1 | SER 26 | B | VdWContact |
| Val 29 | B1.7 | B1 | THR 25 | B | VdWContact |
| Val 29 | B1.7 | B1 | LEU 68 | B | Hydrophobic |
| Lys 31 | b1b2.6 | 30s-loop | LEU 67 | B | Hydrophobic |
| Lys 31 | b1b2.6 | 30s-loop | SER 70 | B | HBDonor |
| Lys 31 | b1b2.6 | 30s-loop | SER 70 | B | VdWContact |
| Lys 31 | b1b2.6 | 30s-loop | THR 25 | B | Hydrophobic |
| Lys 31 | b1b2.6 | 30s-loop | THR 25 | B | HBDonor |
| Lys 31 | b1b2.6 | 30s-loop | THR 25 | B | VdWContact |
| Lys 31 | b1b2.6 | 30s-loop | ILE 24 | B | VdWContact |
| Ala 39 | b1b2.16 | 30s-loop | LEU 68 | B | Hydrophobic |
| Asn 47 | b2b3.4 | 40s-loop | ASN 47 | D | VdWContact |
| Lys 50 | B3.1 | B3 | LEU 8 | C | Hydrophobic |
| Lys 50 | B3.1 | B3 | LEU 8 | C | VdWContact |
| Tyr 60 | H.3 | Helix | LEU 68 | B | Hydrophobic |
| Tyr 60 | H.3 | Helix | ILE 64 | B | Hydrophobic |
| Tyr 60 | H.3 | Helix | ILE 64 | B | VdWContact |
| Ile 64 | H.7 | Helix | TYR 60 | B | Hydrophobic |
| Ile 64 | H.7 | Helix | TYR 60 | B | VdWContact |
| Leu 67 | H.10 | Helix | LYS 31 | B | Hydrophobic |
| Leu 68 | CT.1 | C-term | VAL 29 | B | Hydrophobic |
| Leu 68 | CT.1 | C-term | TYR 60 | B | Hydrophobic |
| Ser 70 | CT.3 | C-term | LYS 31 | B | HBAcceptor |
| Ser 70 | CT.3 | C-term | LYS 31 | B | VdWContact |
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