Interactions

6LFO | CXCL8_HUMAN — CXCR2

Residue contacts: 45
SUMMARY
Protein
CXCL8_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P10145 View on UniProt
PDB ID
6LFO View on PDB
Method
Cryo-em
Resolution
3.4 Å
Date
Sept. 2, 2020
Reference
10.1038/S41586-020-2492-5 Open DOI
State
Monomer
Chain information
Chemokine chain
D
Partner chain
R
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Ala 2 NTc.Cm5 N-term LYS 108 R Hydrophobic
Ala 2 NTc.Cm5 N-term LYS 108 R VdWContact
Lys 3 NTc.Cm4 N-term TYR 197 R Hydrophobic
Lys 3 NTc.Cm4 N-term TYR 197 R VdWContact
Lys 3 NTc.Cm4 N-term TRP 104 R Hydrophobic
Glu 4 NTc.Cm3 N-term ARG 278 R HBAcceptor
Glu 4 NTc.Cm3 N-term ARG 278 R Anionic
Glu 4 NTc.Cm3 N-term ARG 278 R VdWContact
Glu 4 NTc.Cm3 N-term TYR 197 R VdWContact
Glu 4 NTc.Cm3 N-term ARG 289 R Anionic
Glu 4 NTc.Cm3 N-term ARG 289 R VdWContact
Glu 4 NTc.Cm3 N-term LEU 296 R Hydrophobic
Leu 5 NTc.Cm2 N-term TYR 197 R Hydrophobic
Leu 5 NTc.Cm2 N-term TYR 197 R VdWContact
Leu 5 NTc.Cm2 N-term ARG 289 R VdWContact
Arg 6 NTc.Cm1 N-term ARG 289 R Hydrophobic
Arg 6 NTc.Cm1 N-term ARG 289 R VdWContact
Gln 8 CX.4 CX PRO 38 R Hydrophobic
Gln 8 CX.4 CX PRO 38 R VdWContact
Lys 11 cxb1.2 N-loop ALA 36 R Hydrophobic
Lys 11 cxb1.2 N-loop ALA 36 R VdWContact
Lys 11 cxb1.2 N-loop LEU 34 R Hydrophobic
Tyr 13 cxb1.6 N-loop LEU 34 R Hydrophobic
Tyr 13 cxb1.6 N-loop LEU 34 R VdWContact
Lys 15 cxb1.8 N-loop LEU 29 R Hydrophobic
Lys 15 cxb1.8 N-loop LEU 29 R VdWContact
His 18 cxb1.14 N-loop SER 27 R VdWContact
His 18 cxb1.14 N-loop THR 28 R Hydrophobic
His 18 cxb1.14 N-loop THR 28 R VdWContact
Phe 21 B1.1 B1 PHE 32 R Hydrophobic
Phe 21 B1.1 B1 PHE 32 R VdWContact
Gly 31 b1b2.8 30s-loop THR 204 R HBAcceptor
Gly 31 b1b2.8 30s-loop THR 204 R VdWContact
Pro 32 b1b2.9 30s-loop VAL 187 R Hydrophobic
Pro 32 b1b2.9 30s-loop THR 204 R VdWContact
Asp 45 b2b3.4 40s-loop PHE 32 R VdWContact
Arg 47 b2b3.12 40s-loop ASP 35 R HBDonor
Arg 47 b2b3.12 40s-loop ASP 35 R Cationic
Arg 47 b2b3.12 40s-loop ASP 35 R VdWContact
Arg 47 b2b3.12 40s-loop PHE 32 R Hydrophobic
Arg 47 b2b3.12 40s-loop PHE 32 R HBDonor
Arg 47 b2b3.12 40s-loop PHE 32 R VdWContact
Glu 48 B3.1 B3 ALA 37 R Hydrophobic
Glu 48 B3.1 B3 ALA 37 R VdWContact
Leu 49 B3.2 B3 LEU 34 R Hydrophobic
CHEMOKINE DIAGRAM
I E S G P H C A N T 30s-loop S D G R 40s-loop D P K E 50s-loopC-term A K E L R C Q C I K T Y S K P F H P K N-term V R L E K I F E I I V K L L C L E N W V Q R V V E K F
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical