Interactions

6WZM | CXCL8_HUMAN — LY3041658

Residue contacts: 47
SUMMARY
Protein
CXCL8_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P10145 View on UniProt
PDB ID
6WZM View on PDB
Method
X-ray
Resolution
2.28 Å
Date
Nov. 25, 2020
Reference
10.1080/19420862.2020.1831880 Open DOI
State
Dimer
Chain information
Chemokine chain
F
Partner chain
C,D
3D VIEW
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Leu 5 NTc.Cm2 N-term TRP 94 D HBAcceptor
Leu 5 NTc.Cm2 N-term TRP 94 D VdWContact
Leu 5 NTc.Cm2 N-term GLU 93 D Hydrophobic
Leu 5 NTc.Cm2 N-term GLU 93 D VdWContact
Arg 6 NTc.Cm1 N-term TYR 110 C Hydrophobic
Arg 6 NTc.Cm1 N-term TYR 110 C CationPi
Arg 6 NTc.Cm1 N-term ASN 91 D HBDonor
Arg 6 NTc.Cm1 N-term ASN 91 D VdWContact
Arg 6 NTc.Cm1 N-term GLU 99 C HBDonor
Arg 6 NTc.Cm1 N-term GLU 99 C Cationic
Arg 6 NTc.Cm1 N-term GLU 99 C VdWContact
Arg 6 NTc.Cm1 N-term TRP 94 D Hydrophobic
Cys 7 CX.1 CX TRP 94 D Hydrophobic
Cys 7 CX.1 CX TRP 94 D VdWContact
Cys 7 CX.1 CX TRP 33 C Hydrophobic
Gln 8 CX.4 CX PRO 106 C Hydrophobic
Ile 10 cxb1.1 N-loop SER 52 C HBAcceptor
Ile 10 cxb1.1 N-loop SER 52 C VdWContact
Ile 10 cxb1.1 N-loop TRP 33 C Hydrophobic
Ile 10 cxb1.1 N-loop TYR 102 C Hydrophobic
Ile 10 cxb1.1 N-loop TYR 102 C VdWContact
Lys 11 cxb1.2 N-loop GLU 28 C Cationic
Lys 11 cxb1.2 N-loop GLU 28 C VdWContact
Lys 11 cxb1.2 N-loop TYR 104 C VdWContact
Lys 11 cxb1.2 N-loop SER 31 C VdWContact
Lys 11 cxb1.2 N-loop THR 30 C HBDonor
Lys 11 cxb1.2 N-loop THR 30 C VdWContact
Tyr 13 cxb1.6 N-loop TYR 104 C Hydrophobic
Tyr 13 cxb1.6 N-loop TYR 104 C PiStacking
Tyr 13 cxb1.6 N-loop TYR 104 C VdWContact
His 33 b1b2.10 30s-loop TRP 94 D VdWContact
Cys 34 b1b2.12 30s-loop ASN 59 C VdWContact
Ala 35 b1b2.13 30s-loop ASN 59 C HBDonor
Ala 35 b1b2.13 30s-loop ASN 59 C VdWContact
Ala 35 b1b2.13 30s-loop ALA 58 C VdWContact
Asn 36 b1b2.14 30s-loop SER 57 C VdWContact
Ile 40 B2.3 B2 PRO 106 C Hydrophobic
Arg 47 b2b3.12 40s-loop TYR 105 C HBDonor
Arg 47 b2b3.12 40s-loop TYR 105 C VdWContact
Glu 48 B3.1 B3 TYR 105 C VdWContact
Glu 48 B3.1 B3 PRO 106 C Hydrophobic
Glu 48 B3.1 B3 PRO 106 C VdWContact
Leu 49 B3.2 B3 TYR 105 C Hydrophobic
Leu 49 B3.2 B3 TYR 104 C Hydrophobic
Cys 50 B3.3 B3 TYR 104 C Hydrophobic
Cys 50 B3.3 B3 TYR 104 C HBDonor
Cys 50 B3.3 B3 TYR 104 C VdWContact
CHEMOKINE DIAGRAM
I E S G P H C A N T 30s-loop S D G R 40s-loop D P K E 50s-loopC-term A K E L R C Q C I K T Y S K P F H P K N-term V R L E K I F E I I V K L L C L E N W V Q R V V E K F L
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical