Interactions

7F1R | CCL5_HUMAN — CCR5

Residue contacts: 312
SUMMARY
Protein
CCL5_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P13501 View on UniProt
PDB ID
7F1R View on PDB
Method
Cryo-em
Resolution
3.0 Å
Date
July 14, 2021
Reference
10.1038/S41467-021-24438-5 Open DOI
State
Monomer
Chain information
Chemokine chain
R
Partner chain
R
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Ser 1 NTc.Cm9 N-term SER 1 R HBAcceptor
Ser 1 NTc.Cm9 N-term SER 1 R HBDonor
Ser 1 NTc.Cm9 N-term SER 1 R VdWContact
Ser 1 NTc.Cm9 N-term ASP 6 R VdWContact
Ser 1 NTc.Cm9 N-term TYR 346 R HBAcceptor
Ser 1 NTc.Cm9 N-term TYR 346 R VdWContact
Ser 1 NTc.Cm9 N-term GLU 378 R VdWContact
Ser 1 NTc.Cm9 N-term PRO 2 R VdWContact
Pro 2 NTc.Cm8 N-term SER 1 R VdWContact
Pro 2 NTc.Cm8 N-term TYR 3 R VdWContact
Pro 2 NTc.Cm8 N-term ASP 6 R Hydrophobic
Pro 2 NTc.Cm8 N-term ASP 6 R VdWContact
Pro 2 NTc.Cm8 N-term TRP 181 R Hydrophobic
Pro 2 NTc.Cm8 N-term PRO 2 R Hydrophobic
Pro 2 NTc.Cm8 N-term PRO 2 R VdWContact
Pro 2 NTc.Cm8 N-term THR 200 R VdWContact
Tyr 3 NTc.Cm7 N-term ASP 6 R HBAcceptor
Tyr 3 NTc.Cm7 N-term ASP 6 R VdWContact
Tyr 3 NTc.Cm7 N-term TYR 3 R Hydrophobic
Tyr 3 NTc.Cm7 N-term TYR 3 R VdWContact
Tyr 3 NTc.Cm7 N-term VAL 178 R Hydrophobic
Tyr 3 NTc.Cm7 N-term VAL 178 R VdWContact
Tyr 3 NTc.Cm7 N-term PRO 2 R VdWContact
Tyr 3 NTc.Cm7 N-term SER 4 R VdWContact
Tyr 3 NTc.Cm7 N-term SER 5 R VdWContact
Tyr 3 NTc.Cm7 N-term TRP 181 R Hydrophobic
Tyr 3 NTc.Cm7 N-term TRP 181 R VdWContact
Ser 4 NTc.Cm6 N-term THR 7 R HBAcceptor
Ser 4 NTc.Cm6 N-term THR 7 R VdWContact
Ser 4 NTc.Cm6 N-term ASP 6 R VdWContact
Ser 4 NTc.Cm6 N-term TYR 3 R VdWContact
Ser 4 NTc.Cm6 N-term SER 4 R VdWContact
Ser 4 NTc.Cm6 N-term SER 5 R VdWContact
Ser 5 NTc.Cm5 N-term THR 7 R VdWContact
Ser 5 NTc.Cm5 N-term ASP 6 R VdWContact
Ser 5 NTc.Cm5 N-term THR 272 R VdWContact
Ser 5 NTc.Cm5 N-term TYR 3 R VdWContact
Ser 5 NTc.Cm5 N-term SER 4 R VdWContact
Ser 5 NTc.Cm5 N-term SER 5 R VdWContact
Ser 5 NTc.Cm5 N-term CYS 273 R HBAcceptor
Ser 5 NTc.Cm5 N-term CYS 273 R HBDonor
Ser 5 NTc.Cm5 N-term CYS 273 R VdWContact
Asp 6 NTc.Cm4 N-term SER 275 R HBAcceptor
Asp 6 NTc.Cm4 N-term SER 275 R VdWContact
Asp 6 NTc.Cm4 N-term SER 1 R VdWContact
Asp 6 NTc.Cm4 N-term THR 7 R VdWContact
Asp 6 NTc.Cm4 N-term ASP 6 R Hydrophobic
Asp 6 NTc.Cm4 N-term ASP 6 R VdWContact
Asp 6 NTc.Cm4 N-term SER 31 R HBAcceptor
Asp 6 NTc.Cm4 N-term SER 31 R VdWContact
Asp 6 NTc.Cm4 N-term TYR 3 R HBDonor
Asp 6 NTc.Cm4 N-term TYR 3 R VdWContact
Asp 6 NTc.Cm4 N-term SER 274 R HBAcceptor
Asp 6 NTc.Cm4 N-term SER 274 R VdWContact
Asp 6 NTc.Cm4 N-term PRO 2 R Hydrophobic
Asp 6 NTc.Cm4 N-term PRO 2 R VdWContact
Asp 6 NTc.Cm4 N-term SER 4 R VdWContact
Asp 6 NTc.Cm4 N-term SER 5 R VdWContact
Asp 6 NTc.Cm4 N-term CYS 273 R VdWContact
Thr 7 NTc.Cm3 N-term THR 7 R Hydrophobic
Thr 7 NTc.Cm3 N-term THR 7 R VdWContact
Thr 7 NTc.Cm3 N-term ASP 6 R VdWContact
Thr 7 NTc.Cm3 N-term THR 8 R VdWContact
Thr 7 NTc.Cm3 N-term SER 4 R HBDonor
Thr 7 NTc.Cm3 N-term SER 4 R VdWContact
Thr 7 NTc.Cm3 N-term SER 5 R VdWContact
Thr 8 NTc.Cm2 N-term THR 8 R Hydrophobic
Thr 8 NTc.Cm2 N-term THR 8 R HBAcceptor
Thr 8 NTc.Cm2 N-term THR 8 R HBDonor
Thr 8 NTc.Cm2 N-term THR 8 R VdWContact
Thr 8 NTc.Cm2 N-term SER 31 R HBAcceptor
Thr 8 NTc.Cm2 N-term SER 31 R VdWContact
Thr 8 NTc.Cm2 N-term PRO 9 R VdWContact
Thr 8 NTc.Cm2 N-term THR 7 R VdWContact
Thr 8 NTc.Cm2 N-term SER 274 R VdWContact
Pro 9 NTc.Cm1 N-term PRO 9 R Hydrophobic
Pro 9 NTc.Cm1 N-term PRO 9 R VdWContact
Pro 9 NTc.Cm1 N-term THR 8 R VdWContact
Pro 9 NTc.Cm1 N-term CYS 10 R VdWContact
Cys 10 CX.1 CX CYS 11 R VdWContact
Cys 10 CX.1 CX PRO 9 R VdWContact
Cys 10 CX.1 CX CYS 34 R Hydrophobic
Cys 10 CX.1 CX CYS 34 R VdWContact
Cys 10 CX.1 CX CYS 10 R Hydrophobic
Cys 10 CX.1 CX CYS 10 R VdWContact
Cys 10 CX.1 CX PHE 12 R Hydrophobic
Cys 10 CX.1 CX PHE 12 R VdWContact
Cys 11 CX.5 CX ALA 38 R Hydrophobic
Cys 11 CX.5 CX ALA 38 R VdWContact
Cys 11 CX.5 CX CYS 11 R Hydrophobic
Cys 11 CX.5 CX CYS 11 R VdWContact
Cys 11 CX.5 CX CYS 50 R Hydrophobic
Cys 11 CX.5 CX CYS 50 R VdWContact
Cys 11 CX.5 CX CYS 10 R VdWContact
Cys 11 CX.5 CX PHE 12 R VdWContact
Cys 11 CX.5 CX TYR 14 R Hydrophobic
Phe 12 cxb1.1 N-loop PHE 12 R Hydrophobic
Phe 12 cxb1.1 N-loop PHE 12 R VdWContact
Phe 12 cxb1.1 N-loop CYS 11 R VdWContact
Phe 12 cxb1.1 N-loop CYS 10 R Hydrophobic
Phe 12 cxb1.1 N-loop CYS 10 R VdWContact
Phe 12 cxb1.1 N-loop CYS 34 R Hydrophobic
Phe 12 cxb1.1 N-loop ALA 13 R VdWContact
Ala 13 cxb1.2 N-loop ALA 13 R Hydrophobic
Ala 13 cxb1.2 N-loop ALA 13 R VdWContact
Ala 13 cxb1.2 N-loop PHE 12 R VdWContact
Ala 13 cxb1.2 N-loop TYR 14 R VdWContact
Tyr 14 cxb1.5 N-loop ALA 38 R Hydrophobic
Tyr 14 cxb1.5 N-loop ASN 36 R VdWContact
Tyr 14 cxb1.5 N-loop CYS 11 R Hydrophobic
Tyr 14 cxb1.5 N-loop CYS 50 R Hydrophobic
Tyr 14 cxb1.5 N-loop CYS 50 R VdWContact
Tyr 14 cxb1.5 N-loop ALA 13 R VdWContact
Tyr 14 cxb1.5 N-loop TYR 14 R Hydrophobic
Tyr 14 cxb1.5 N-loop TYR 14 R VdWContact
Lys 25 B1.3 B1 GLU 26 R VdWContact
Lys 25 B1.3 B1 LYS 25 R Hydrophobic
Lys 25 B1.3 B1 LYS 25 R VdWContact
Glu 26 B1.4 B1 PHE 41 R VdWContact
Glu 26 B1.4 B1 TYR 27 R VdWContact
Glu 26 B1.4 B1 GLU 26 R Hydrophobic
Glu 26 B1.4 B1 GLU 26 R VdWContact
Glu 26 B1.4 B1 LYS 25 R VdWContact
Tyr 27 B1.5 B1 TYR 29 R Hydrophobic
Tyr 27 B1.5 B1 TYR 29 R VdWContact
Tyr 27 B1.5 B1 CYS 28 R VdWContact
Tyr 27 B1.5 B1 TYR 27 R Hydrophobic
Tyr 27 B1.5 B1 TYR 27 R VdWContact
Tyr 27 B1.5 B1 GLU 26 R VdWContact
Phe 28 B1.6 B1 CYS 267 R Hydrophobic
Phe 28 B1.6 B1 CYS 267 R VdWContact
Phe 28 B1.6 B1 TYR 29 R VdWContact
Phe 28 B1.6 B1 VAL 40 R Hydrophobic
Phe 28 B1.6 B1 VAL 40 R VdWContact
Phe 28 B1.6 B1 CYS 28 R Hydrophobic
Phe 28 B1.6 B1 CYS 28 R VdWContact
Phe 28 B1.6 B1 TYR 27 R VdWContact
Tyr 29 B1.7 B1 GLN 265 R Hydrophobic
Tyr 29 B1.7 B1 GLN 265 R VdWContact
Tyr 29 B1.7 B1 HIS 276 R Hydrophobic
Tyr 29 B1.7 B1 HIS 276 R PiStacking
Tyr 29 B1.7 B1 THR 30 R VdWContact
Tyr 29 B1.7 B1 TYR 29 R Hydrophobic
Tyr 29 B1.7 B1 TYR 29 R VdWContact
Tyr 29 B1.7 B1 CYS 28 R VdWContact
Tyr 29 B1.7 B1 TYR 27 R Hydrophobic
Tyr 29 B1.7 B1 TYR 27 R VdWContact
Thr 30 b1b2.4 30s-loop THR 30 R Hydrophobic
Thr 30 b1b2.4 30s-loop THR 30 R VdWContact
Thr 30 b1b2.4 30s-loop TYR 29 R VdWContact
Thr 30 b1b2.4 30s-loop SER 31 R VdWContact
Ser 31 b1b2.6 30s-loop THR 8 R HBDonor
Ser 31 b1b2.6 30s-loop THR 8 R VdWContact
Ser 31 b1b2.6 30s-loop ASP 6 R HBDonor
Ser 31 b1b2.6 30s-loop ASP 6 R VdWContact
Ser 31 b1b2.6 30s-loop THR 30 R VdWContact
Ser 31 b1b2.6 30s-loop SER 31 R VdWContact
Ser 31 b1b2.6 30s-loop SER 275 R VdWContact
Ser 31 b1b2.6 30s-loop LYS 33 R VdWContact
Ser 31 b1b2.6 30s-loop GLY 32 R VdWContact
Gly 32 b1b2.9 30s-loop LYS 33 R VdWContact
Gly 32 b1b2.9 30s-loop GLY 32 R VdWContact
Gly 32 b1b2.9 30s-loop TYR 282 R VdWContact
Gly 32 b1b2.9 30s-loop CYS 34 R VdWContact
Gly 32 b1b2.9 30s-loop LYS 286 R HBAcceptor
Gly 32 b1b2.9 30s-loop LYS 286 R VdWContact
Gly 32 b1b2.9 30s-loop SER 31 R VdWContact
Lys 33 b1b2.10 30s-loop SER 31 R VdWContact
Lys 33 b1b2.10 30s-loop LYS 33 R VdWContact
Lys 33 b1b2.10 30s-loop GLY 32 R VdWContact
Lys 33 b1b2.10 30s-loop CYS 34 R VdWContact
Cys 34 b1b2.12 30s-loop PHE 12 R Hydrophobic
Cys 34 b1b2.12 30s-loop TYR 282 R HBAcceptor
Cys 34 b1b2.12 30s-loop SER 35 R VdWContact
Cys 34 b1b2.12 30s-loop CYS 10 R Hydrophobic
Cys 34 b1b2.12 30s-loop CYS 10 R VdWContact
Cys 34 b1b2.12 30s-loop LYS 33 R VdWContact
Cys 34 b1b2.12 30s-loop GLY 32 R VdWContact
Cys 34 b1b2.12 30s-loop CYS 34 R Hydrophobic
Cys 34 b1b2.12 30s-loop CYS 34 R VdWContact
Cys 34 b1b2.12 30s-loop LYS 286 R VdWContact
Ser 35 b1b2.13 30s-loop ASN 36 R VdWContact
Ser 35 b1b2.13 30s-loop CYS 34 R VdWContact
Ser 35 b1b2.13 30s-loop SER 35 R VdWContact
Asn 36 b1b2.14 30s-loop ASN 36 R VdWContact
Asn 36 b1b2.14 30s-loop PRO 37 R VdWContact
Asn 36 b1b2.14 30s-loop SER 35 R VdWContact
Asn 36 b1b2.14 30s-loop TYR 14 R VdWContact
Pro 37 b1b2.16 30s-loop TYR 282 R Hydrophobic
Pro 37 b1b2.16 30s-loop TYR 282 R VdWContact
Pro 37 b1b2.16 30s-loop ALA 38 R VdWContact
Pro 37 b1b2.16 30s-loop ASN 36 R VdWContact
Pro 37 b1b2.16 30s-loop PRO 37 R Hydrophobic
Pro 37 b1b2.16 30s-loop PRO 37 R VdWContact
Ala 38 B2.1 B2 ALA 38 R Hydrophobic
Ala 38 B2.1 B2 ALA 38 R VdWContact
Ala 38 B2.1 B2 VAL 39 R VdWContact
Ala 38 B2.1 B2 CYS 11 R Hydrophobic
Ala 38 B2.1 B2 CYS 11 R VdWContact
Ala 38 B2.1 B2 PRO 37 R VdWContact
Ala 38 B2.1 B2 CYS 50 R Hydrophobic
Ala 38 B2.1 B2 PRO 53 R VdWContact
Ala 38 B2.1 B2 TYR 14 R Hydrophobic
Val 39 B2.2 B2 VAL 39 R VdWContact
Val 39 B2.2 B2 ALA 38 R VdWContact
Val 39 B2.2 B2 CYS 50 R VdWContact
Val 39 B2.2 B2 VAL 40 R VdWContact
Val 40 B2.3 B2 PHE 41 R VdWContact
Val 40 B2.3 B2 VAL 39 R VdWContact
Val 40 B2.3 B2 CYS 28 R Hydrophobic
Val 40 B2.3 B2 CYS 28 R VdWContact
Val 40 B2.3 B2 VAL 40 R Hydrophobic
Val 40 B2.3 B2 VAL 40 R VdWContact
Phe 41 B2.4 B2 PHE 41 R Hydrophobic
Phe 41 B2.4 B2 PHE 41 R VdWContact
Phe 41 B2.4 B2 GLU 26 R VdWContact
Phe 41 B2.4 B2 VAL 40 R VdWContact
Arg 47 b2b3.12 40s-loop ARG 47 R VdWContact
Arg 47 b2b3.12 40s-loop GLN 48 R VdWContact
Gln 48 B3.1 B3 VAL 49 R VdWContact
Gln 48 B3.1 B3 ARG 47 R VdWContact
Gln 48 B3.1 B3 GLN 48 R VdWContact
Val 49 B3.2 B3 VAL 49 R VdWContact
Val 49 B3.2 B3 GLN 48 R VdWContact
Val 49 B3.2 B3 CYS 50 R VdWContact
Cys 50 B3.3 B3 ALA 38 R Hydrophobic
Cys 50 B3.3 B3 VAL 49 R VdWContact
Cys 50 B3.3 B3 VAL 39 R VdWContact
Cys 50 B3.3 B3 CYS 11 R Hydrophobic
Cys 50 B3.3 B3 CYS 11 R VdWContact
Cys 50 B3.3 B3 CYS 50 R Hydrophobic
Cys 50 B3.3 B3 CYS 50 R VdWContact
Cys 50 B3.3 B3 ALA 51 R VdWContact
Cys 50 B3.3 B3 TYR 14 R Hydrophobic
Cys 50 B3.3 B3 TYR 14 R VdWContact
Ala 51 B3.4 B3 CYS 50 R VdWContact
Ala 51 B3.4 B3 ASN 52 R VdWContact
Ala 51 B3.4 B3 ALA 51 R Hydrophobic
Ala 51 B3.4 B3 ALA 51 R VdWContact
Asn 52 b3h.1 50s-loop PRO 53 R VdWContact
Asn 52 b3h.1 50s-loop ALA 51 R VdWContact
Asn 52 b3h.1 50s-loop LYS 56 R VdWContact
Asn 52 b3h.1 50s-loop ASN 52 R VdWContact
Pro 53 b3h.2 50s-loop ALA 38 R VdWContact
Pro 53 b3h.2 50s-loop GLU 54 R VdWContact
Pro 53 b3h.2 50s-loop PRO 53 R Hydrophobic
Pro 53 b3h.2 50s-loop PRO 53 R VdWContact
Pro 53 b3h.2 50s-loop ASN 52 R VdWContact
Glu 54 b3h.3 50s-loop GLU 54 R VdWContact
Glu 54 b3h.3 50s-loop LYS 55 R VdWContact
Glu 54 b3h.3 50s-loop PRO 53 R VdWContact
Glu 54 b3h.3 50s-loop LYS 56 R VdWContact
Lys 55 b3h.4 50s-loop GLU 54 R VdWContact
Lys 55 b3h.4 50s-loop LYS 55 R VdWContact
Lys 55 b3h.4 50s-loop LYS 56 R VdWContact
Lys 56 H.1 Helix GLU 54 R VdWContact
Lys 56 H.1 Helix TRP 57 R VdWContact
Lys 56 H.1 Helix LYS 55 R VdWContact
Lys 56 H.1 Helix ASN 52 R VdWContact
Lys 56 H.1 Helix LYS 56 R VdWContact
Lys 56 H.1 Helix GLU 60 R HBAcceptor
Lys 56 H.1 Helix GLU 60 R VdWContact
Trp 57 H.2 Helix TRP 57 R VdWContact
Trp 57 H.2 Helix TYR 61 R HBAcceptor
Trp 57 H.2 Helix TYR 61 R VdWContact
Trp 57 H.2 Helix LYS 56 R VdWContact
Trp 57 H.2 Helix VAL 58 R VdWContact
Val 58 H.3 Helix ARG 59 R VdWContact
Val 58 H.3 Helix TRP 57 R VdWContact
Val 58 H.3 Helix ILE 62 R HBAcceptor
Val 58 H.3 Helix ILE 62 R VdWContact
Val 58 H.3 Helix VAL 58 R VdWContact
Arg 59 H.4 Helix ARG 59 R VdWContact
Arg 59 H.4 Helix ASN 63 R HBAcceptor
Arg 59 H.4 Helix ASN 63 R VdWContact
Arg 59 H.4 Helix VAL 58 R VdWContact
Arg 59 H.4 Helix GLU 60 R VdWContact
Glu 60 H.5 Helix ARG 59 R VdWContact
Glu 60 H.5 Helix TYR 61 R VdWContact
Glu 60 H.5 Helix LYS 56 R HBDonor
Glu 60 H.5 Helix LYS 56 R VdWContact
Glu 60 H.5 Helix SER 64 R HBAcceptor
Glu 60 H.5 Helix SER 64 R VdWContact
Glu 60 H.5 Helix GLU 60 R VdWContact
Tyr 61 H.6 Helix TRP 57 R HBDonor
Tyr 61 H.6 Helix TRP 57 R VdWContact
Tyr 61 H.6 Helix TYR 61 R VdWContact
Tyr 61 H.6 Helix ILE 62 R VdWContact
Tyr 61 H.6 Helix SER 64 R HBAcceptor
Tyr 61 H.6 Helix SER 64 R VdWContact
Tyr 61 H.6 Helix GLU 60 R VdWContact
Ile 62 H.7 Helix TYR 61 R VdWContact
Ile 62 H.7 Helix ILE 62 R VdWContact
Ile 62 H.7 Helix ASN 63 R VdWContact
Ile 62 H.7 Helix SER 64 R VdWContact
Ile 62 H.7 Helix VAL 58 R HBDonor
Ile 62 H.7 Helix VAL 58 R VdWContact
Asn 63 H.8 Helix ARG 59 R HBDonor
Asn 63 H.8 Helix ARG 59 R VdWContact
Asn 63 H.8 Helix ILE 62 R VdWContact
Asn 63 H.8 Helix ASN 63 R VdWContact
Asn 63 H.8 Helix SER 64 R VdWContact
Ser 64 H.9 Helix TYR 61 R HBDonor
Ser 64 H.9 Helix TYR 61 R VdWContact
Ser 64 H.9 Helix ILE 62 R VdWContact
Ser 64 H.9 Helix ASN 63 R VdWContact
Ser 64 H.9 Helix LEU 65 R VdWContact
Ser 64 H.9 Helix SER 64 R VdWContact
Ser 64 H.9 Helix GLU 60 R HBDonor
Ser 64 H.9 Helix GLU 60 R VdWContact
Leu 65 H.10 Helix LEU 65 R VdWContact
Leu 65 H.10 Helix SER 64 R VdWContact
CHEMOKINE DIAGRAM
T S G K C S N P 30s-loop R 40s-loop N P E K 50s-loopC-term S P Y S S D T T P C C F A Y N-term Y C Y E K A V V F A C V Q K W V R E Y I N S L
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical