Interactions

7O7F | CCL5_HUMAN — CCR5

Residue contacts: 61
SUMMARY
Protein
CCL5_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P13501 View on UniProt
PDB ID
7O7F View on PDB
Method
Cryo-em
Resolution
3.15 Å
Date
June 30, 2021
Reference
10.1126/SCIADV.ABG8685 Open DOI
State
Monomer
Chain information
Chemokine chain
I
Partner chain
C
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Lys 2 NTc.Cm31 N-term GLU 283 C VdWContact
Lys 2 NTc.Cm31 N-term TRP 86 C Hydrophobic
Lys 2 NTc.Cm31 N-term THR 105 C Hydrophobic
Val 3 NTc.Cm30 N-term GLU 283 C VdWContact
Val 3 NTc.Cm30 N-term TRP 86 C Hydrophobic
Val 3 NTc.Cm30 N-term TRP 86 C VdWContact
Val 3 NTc.Cm30 N-term TYR 37 C Hydrophobic
Val 3 NTc.Cm30 N-term TYR 108 C Hydrophobic
Val 3 NTc.Cm30 N-term TYR 108 C VdWContact
Ala 5 NTc.Cm28 N-term ALA 30 C Hydrophobic
Ala 5 NTc.Cm28 N-term TYR 89 C VdWContact
Ala 5 NTc.Cm28 N-term GLN 280 C HBAcceptor
Ala 5 NTc.Cm28 N-term GLN 280 C VdWContact
Ala 5 NTc.Cm28 N-term LYS 26 C Hydrophobic
Ala 5 NTc.Cm28 N-term LYS 26 C HBAcceptor
Ala 5 NTc.Cm28 N-term LYS 26 C Anionic
Ala 5 NTc.Cm28 N-term LYS 26 C VdWContact
Ala 6 NTc.Cm27 N-term TYR 89 C Hydrophobic
Ala 6 NTc.Cm27 N-term TRP 86 C Hydrophobic
Ala 6 NTc.Cm27 N-term TRP 86 C VdWContact
Ala 7 NTc.Cm26 N-term LYS 22 C Hydrophobic
Ala 7 NTc.Cm26 N-term LYS 22 C VdWContact
Ala 7 NTc.Cm26 N-term GLN 280 C Hydrophobic
Ala 7 NTc.Cm26 N-term ASP 276 C Hydrophobic
Ala 7 NTc.Cm26 N-term ASP 276 C VdWContact
Ala 7 NTc.Cm26 N-term LYS 26 C Hydrophobic
Ala 7 NTc.Cm26 N-term LYS 26 C VdWContact
Leu 8 NTc.Cm25 N-term THR 177 C Hydrophobic
Leu 8 NTc.Cm25 N-term THR 177 C VdWContact
Cys 10 CX.1 CX PRO 19 C VdWContact
Phe 12 cxb1.1 N-loop CYS 269 C Hydrophobic
Phe 12 cxb1.1 N-loop CYS 20 C Hydrophobic
Phe 12 cxb1.1 N-loop CYS 20 C VdWContact
Phe 28 B1.6 B1 GLU 172 C Hydrophobic
Tyr 29 B1.7 B1 HIS 181 C Hydrophobic
Tyr 29 B1.7 B1 HIS 181 C VdWContact
Thr 30 b1b2.4 30s-loop HIS 181 C VdWContact
Gly 32 b1b2.9 30s-loop PHE 182 C VdWContact
Gly 32 b1b2.9 30s-loop SER 180 C HBDonor
Gly 32 b1b2.9 30s-loop SER 180 C VdWContact
Gly 32 b1b2.9 30s-loop TYR 187 C VdWContact
Lys 33 b1b2.10 30s-loop LYS 191 C VdWContact
Lys 33 b1b2.10 30s-loop ASN 258 C VdWContact
Cys 34 b1b2.12 30s-loop LYS 191 C HBAcceptor
Cys 34 b1b2.12 30s-loop LYS 191 C VdWContact
Cys 34 b1b2.12 30s-loop TYR 187 C VdWContact
Ser 35 b1b2.13 30s-loop GLN 188 C VdWContact
Ser 35 b1b2.13 30s-loop TYR 187 C HBAcceptor
Ser 35 b1b2.13 30s-loop TYR 187 C VdWContact
Pro 37 b1b2.16 30s-loop TYR 187 C Hydrophobic
Pro 37 b1b2.16 30s-loop TYR 187 C VdWContact
Arg 47 b2b3.12 40s-loop GLU 18 C Hydrophobic
Arg 47 b2b3.12 40s-loop GLU 18 C Cationic
Arg 47 b2b3.12 40s-loop GLU 18 C VdWContact
Arg 47 b2b3.12 40s-loop THR 16 C Cationic
Gln 48 B3.1 B3 GLU 18 C HBDonor
Gln 48 B3.1 B3 GLU 18 C VdWContact
Pro 53 b3h.2 50s-loop TYR 184 C Hydrophobic
Pro 53 b3h.2 50s-loop TYR 184 C VdWContact
Glu 54 b3h.3 50s-loop TYR 184 C Hydrophobic
Glu 54 b3h.3 50s-loop TYR 184 C VdWContact
CHEMOKINE DIAGRAM
T S G K C S N P 30s-loop R K N R 40s-loop N P E K 50s-loopC-term G P P G D I V L A C C F A Y I A R P L P R A N-term Y F Y E K I H A V V F V T A C V Q K W V R E Y I N S L E
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical