Interactions

7RKN | CX3CL1_HUMAN — US28

Residue contacts: 50
SUMMARY
Protein
CX3CL1_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P78423 View on UniProt
PDB ID
7RKN View on PDB
Method
Cryo-em
Resolution
3.6 Å
Date
Jan. 26, 2022
Reference
10.1126/SCIADV.ABL5442 Open DOI
State
Monomer
Chain information
Chemokine chain
L
Partner chain
R
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
His 2 NTc.Cm12 N-term GLU 277 R HBDonor
His 2 NTc.Cm12 N-term GLU 277 R VdWContact
His 2 NTc.Cm12 N-term PHE 281 R Hydrophobic
His 2 NTc.Cm12 N-term PHE 111 R Hydrophobic
His 2 NTc.Cm12 N-term TYR 40 R Hydrophobic
His 2 NTc.Cm12 N-term TYR 40 R VdWContact
His 2 NTc.Cm12 N-term TYR 112 R Hydrophobic
His 2 NTc.Cm12 N-term TYR 112 R VdWContact
His 2 NTc.Cm12 N-term TRP 89 R PiStacking
His 3 NTc.Cm11 N-term LEU 273 R Hydrophobic
His 3 NTc.Cm11 N-term LEU 273 R VdWContact
His 3 NTc.Cm11 N-term LEU 248 R Hydrophobic
His 3 NTc.Cm11 N-term ASN 189 R HBDonor
His 3 NTc.Cm11 N-term ASN 189 R VdWContact
Gly 4 NTc.Cm10 N-term GLU 277 R HBDonor
Gly 4 NTc.Cm10 N-term GLU 277 R VdWContact
Val 5 NTc.Cm9 N-term TRP 89 R Hydrophobic
Val 5 NTc.Cm9 N-term TRP 89 R VdWContact
Val 5 NTc.Cm9 N-term TYR 92 R Hydrophobic
Val 5 NTc.Cm9 N-term LEU 93 R Hydrophobic
Thr 6 NTc.Cm8 N-term LEU 29 R VdWContact
Thr 6 NTc.Cm8 N-term LYS 270 R VdWContact
Asn 9 NTc.Cm5 N-term PHE 25 R Hydrophobic
Asn 9 NTc.Cm5 N-term PHE 25 R VdWContact
Asn 9 NTc.Cm5 N-term VAL 24 R Hydrophobic
Ile 10 NTc.Cm4 N-term PHE 25 R VdWContact
Thr 11 NTc.Cm3 N-term PHE 25 R Hydrophobic
Thr 11 NTc.Cm3 N-term PRO 22 R VdWContact
Thr 11 NTc.Cm3 N-term CYS 23 R HBAcceptor
Thr 11 NTc.Cm3 N-term CYS 23 R VdWContact
Lys 14 CX.1 CX ALA 20 R Hydrophobic
Thr 16 CX.3 CX GLU 18 R Hydrophobic
Lys 18 CX.5 CX TYR 16 R VdWContact
Ile 19 cxb1.1 N-loop GLU 18 R VdWContact
Ile 19 cxb1.1 N-loop TYR 16 R Hydrophobic
Ile 19 cxb1.1 N-loop TYR 16 R VdWContact
Ala 32 B1.4 B1 LYS 169 R VdWContact
Ala 32 B1.4 B1 MET 174 R VdWContact
Ser 33 B1.5 B1 MET 174 R VdWContact
Gly 35 B1.7 B1 MET 174 R VdWContact
Gly 35 B1.7 B1 ASP 178 R VdWContact
Ile 40 b1b2.12 30s-loop PRO 22 R Hydrophobic
Ile 40 b1b2.12 30s-loop PRO 22 R VdWContact
Leu 48 B2.4 B2 PRO 22 R VdWContact
Leu 48 B2.4 B2 THR 21 R VdWContact
Phe 49 B2.5 B2 THR 21 R VdWContact
Phe 49 B2.5 B2 PRO 22 R VdWContact
Phe 49 B2.5 B2 ASP 17 R Hydrophobic
Phe 49 B2.5 B2 ASP 17 R VdWContact
Cys 50 B2.6 B2 PRO 22 R Hydrophobic
CHEMOKINE DIAGRAM
K R A I I L E T R 30s-loop A D P 40s-loop V K D A 50s-loopC-term H H G V T K C N I T C S K M T S K I P V A L L I H Y Q N-term G C S A Q N Q Q H R L F C W Q E K M Q H L D R Q
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical