Interactions

7SK5 | CXCL12_HUMAN — ACKR3

Residue contacts: 56
SUMMARY
Protein
CXCL12_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P48061 View on UniProt
PDB ID
7SK5 View on PDB
Method
Cryo-em
Resolution
4.0 Å
Date
July 27, 2022
Reference
10.1126/SCIADV.ABN8063 Open DOI
State
Monomer
Chain information
Chemokine chain
B
Partner chain
A
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Lys 1 NTc.Cm8 N-term TYR 268 A HBAcceptor
Lys 1 NTc.Cm8 N-term TYR 268 A VdWContact
Lys 1 NTc.Cm8 N-term ASP 179 A Cationic
Lys 1 NTc.Cm8 N-term ASP 179 A VdWContact
Pro 2 NTc.Cm7 N-term TRP 100 A Hydrophobic
Pro 2 NTc.Cm7 N-term GLN 301 A VdWContact
Pro 2 NTc.Cm7 N-term PHE 124 A Hydrophobic
Val 3 NTc.Cm6 N-term LEU 297 A Hydrophobic
Val 3 NTc.Cm6 N-term LEU 297 A VdWContact
Val 3 NTc.Cm6 N-term HIS 298 A Hydrophobic
Val 3 NTc.Cm6 N-term HIS 298 A VdWContact
Val 3 NTc.Cm6 N-term GLN 301 A HBDonor
Val 3 NTc.Cm6 N-term GLN 301 A VdWContact
Ser 4 NTc.Cm5 N-term SER 103 A HBDonor
Ser 4 NTc.Cm5 N-term SER 103 A VdWContact
Leu 5 NTc.Cm4 N-term TRP 110 A Hydrophobic
Leu 5 NTc.Cm4 N-term TRP 100 A Hydrophobic
Leu 5 NTc.Cm4 N-term TRP 100 A VdWContact
Leu 5 NTc.Cm4 N-term CYS 196 A Hydrophobic
Leu 5 NTc.Cm4 N-term CYS 196 A VdWContact
Leu 5 NTc.Cm4 N-term CYS 117 A VdWContact
Leu 5 NTc.Cm4 N-term LEU 183 A Hydrophobic
Leu 5 NTc.Cm4 N-term HIS 121 A Hydrophobic
Tyr 7 NTc.Cm2 N-term ARG 197 A Hydrophobic
Tyr 7 NTc.Cm2 N-term ARG 197 A PiCation
Tyr 7 NTc.Cm2 N-term ARG 197 A VdWContact
Arg 8 NTc.Cm1 N-term LEU 297 A VdWContact
Arg 8 NTc.Cm1 N-term ASP 275 A Cationic
Arg 8 NTc.Cm1 N-term ASP 275 A VdWContact
Pro 10 CX.4 CX PHE 285 A Hydrophobic
Cys 11 CX.5 CX HIS 281 A Hydrophobic
Cys 11 CX.5 CX HIS 281 A VdWContact
Arg 12 cxb1.1 N-loop ILE 279 A VdWContact
Phe 13 cxb1.2 N-loop LYS 206 A Hydrophobic
Phe 13 cxb1.2 N-loop LYS 206 A VdWContact
Phe 13 cxb1.2 N-loop ILE 205 A Hydrophobic
Phe 13 cxb1.2 N-loop ILE 279 A Hydrophobic
His 25 B1.4 B1 VAL 28 A Hydrophobic
His 25 B1.4 B1 VAL 28 A VdWContact
Leu 26 B1.5 B1 VAL 29 A VdWContact
Lys 27 B1.6 B1 ASP 30 A Hydrophobic
Lys 27 B1.6 B1 ASP 30 A VdWContact
Ile 28 B1.7 B1 THR 31 A Hydrophobic
Ile 28 B1.7 B1 THR 31 A VdWContact
Ile 28 B1.7 B1 ASP 30 A HBDonor
Ile 28 B1.7 B1 ASP 30 A VdWContact
Ile 28 B1.7 B1 VAL 29 A Hydrophobic
Ile 28 B1.7 B1 VAL 32 A HBAcceptor
Ile 28 B1.7 B1 VAL 32 A VdWContact
Leu 29 b1b2.4 30s-loop PHE 285 A Hydrophobic
Leu 29 b1b2.4 30s-loop VAL 32 A Hydrophobic
Leu 29 b1b2.4 30s-loop VAL 32 A VdWContact
Asn 30 b1b2.7 30s-loop MET 33 A Hydrophobic
Arg 47 b2b3.12 40s-loop TYR 282 A CationPi
Arg 47 b2b3.12 40s-loop TYR 282 A VdWContact
Gln 48 B3.1 B3 HIS 281 A Hydrophobic
CHEMOKINE DIAGRAM
L N T P N C A L 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term K P V S L S Y R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical