Interactions for 6LFM — Binding Partner: CXCR2
Structure details
- PDB ID: 6LFM open_in_new
- Protein: CXCL8_HUMAN
- Organism: Homo sapiens
- UniProt ID: P10145 open_in_new
- Method: Cryo-em
- Resolution: 3.5 Å
- Date: Sept. 2, 2020
- Reference: 10.1038/S41586-020-2492-5 open_in_new
- State: Dimer
- Chemokine Chain: D
- Partner Chain: R
Chemokine diagram
Interactions for this Binding Partner
Download list as CSV
| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Ala 2 | NTc.Cm5 | N-term | VAL 192 | R | Hydrophobic |
| Lys 3 | NTc.Cm4 | N-term | ASP 293 | R | VdWContact |
| Lys 3 | NTc.Cm4 | N-term | TYR 197 | R | HBAcceptor |
| Lys 3 | NTc.Cm4 | N-term | TYR 197 | R | VdWContact |
| Lys 3 | NTc.Cm4 | N-term | LEU 296 | R | Hydrophobic |
| Lys 3 | NTc.Cm4 | N-term | LEU 296 | R | VdWContact |
| Lys 3 | NTc.Cm4 | N-term | GLU 300 | R | Cationic |
| Glu 4 | NTc.Cm3 | N-term | TYR 197 | R | VdWContact |
| Glu 4 | NTc.Cm3 | N-term | LEU 296 | R | Hydrophobic |
| Glu 4 | NTc.Cm3 | N-term | ARG 278 | R | VdWContact |
| Glu 4 | NTc.Cm3 | N-term | ARG 289 | R | HBAcceptor |
| Glu 4 | NTc.Cm3 | N-term | ARG 289 | R | VdWContact |
| Glu 4 | NTc.Cm3 | N-term | ARG 208 | R | HBAcceptor |
| Glu 4 | NTc.Cm3 | N-term | ARG 208 | R | Anionic |
| Glu 4 | NTc.Cm3 | N-term | ARG 208 | R | VdWContact |
| Leu 5 | NTc.Cm2 | N-term | TYR 197 | R | Hydrophobic |
| Leu 5 | NTc.Cm2 | N-term | TYR 197 | R | HBDonor |
| Leu 5 | NTc.Cm2 | N-term | TYR 197 | R | VdWContact |
| Leu 5 | NTc.Cm2 | N-term | VAL 192 | R | Hydrophobic |
| Leu 5 | NTc.Cm2 | N-term | VAL 192 | R | VdWContact |
| Arg 6 | NTc.Cm1 | N-term | ARG 289 | R | Hydrophobic |
| Arg 6 | NTc.Cm1 | N-term | ARG 289 | R | HBAcceptor |
| Arg 6 | NTc.Cm1 | N-term | ARG 289 | R | VdWContact |
| Gln 8 | CX.4 | CX | PRO 38 | R | Hydrophobic |
| Gln 8 | CX.4 | CX | PRO 38 | R | VdWContact |
| Gln 8 | CX.4 | CX | ASN 191 | R | HBAcceptor |
| Gln 8 | CX.4 | CX | ASN 191 | R | VdWContact |
| Lys 11 | cxb1.2 | N-loop | ALA 36 | R | Hydrophobic |
| Tyr 13 | cxb1.6 | N-loop | LEU 34 | R | Hydrophobic |
| Tyr 13 | cxb1.6 | N-loop | LEU 34 | R | VdWContact |
| Lys 15 | cxb1.8 | N-loop | LEU 29 | R | Hydrophobic |
| Phe 17 | cxb1.11 | N-loop | LEU 29 | R | Hydrophobic |
| His 18 | cxb1.14 | N-loop | THR 28 | R | Hydrophobic |
| His 18 | cxb1.14 | N-loop | THR 28 | R | VdWContact |
| Phe 21 | B1.1 | B1 | PHE 32 | R | Hydrophobic |
| Gly 31 | b1b2.8 | 30s-loop | THR 204 | R | VdWContact |
| Gly 31 | b1b2.8 | 30s-loop | GLY 201 | R | VdWContact |
| Pro 32 | b1b2.9 | 30s-loop | VAL 187 | R | Hydrophobic |
| Pro 32 | b1b2.9 | 30s-loop | THR 204 | R | VdWContact |
| Ile 40 | B2.3 | B2 | PRO 38 | R | Hydrophobic |
| Arg 47 | b2b3.12 | 40s-loop | PHE 32 | R | Hydrophobic |
| Glu 48 | B3.1 | B3 | ALA 37 | R | Hydrophobic |
| Glu 48 | B3.1 | B3 | ALA 37 | R | VdWContact |
| Glu 48 | B3.1 | B3 | PRO 38 | R | Hydrophobic |
| Glu 48 | B3.1 | B3 | PRO 38 | R | VdWContact |
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