Interactions

7SK8 | CXCL12_HUMAN — ACKR3

Residue contacts: 62
SUMMARY
Protein
CXCL12_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P48061 View on UniProt
PDB ID
7SK8 View on PDB
Method
Cryo-em
Resolution
3.3 Å
Date
July 27, 2022
Reference
10.1126/SCIADV.ABN8063 Open DOI
State
Monomer
Chain information
Chemokine chain
B
Partner chain
A
3D VIEW
Powered by NGL viewer
INTERACTION TABLE
Download CSV
Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Tyr 7 NTc.Cm2 N-term ARG 197 A VdWContact
Tyr 7 NTc.Cm2 N-term TYR 195 A Hydrophobic
Tyr 7 NTc.Cm2 N-term TYR 195 A VdWContact
Arg 8 NTc.Cm1 N-term ASP 275 A Cationic
Pro 10 CX.4 CX PHE 285 A Hydrophobic
Pro 10 CX.4 CX PHE 285 A VdWContact
Arg 12 cxb1.1 N-loop LEU 209 A Hydrophobic
Arg 12 cxb1.1 N-loop ASP 275 A Cationic
Arg 12 cxb1.1 N-loop ILE 279 A Hydrophobic
Arg 12 cxb1.1 N-loop ILE 279 A VdWContact
Phe 13 cxb1.2 N-loop LEU 209 A Hydrophobic
Phe 13 cxb1.2 N-loop LEU 280 A Hydrophobic
Phe 13 cxb1.2 N-loop ILE 205 A Hydrophobic
Phe 13 cxb1.2 N-loop LYS 206 A Hydrophobic
Phe 13 cxb1.2 N-loop ILE 279 A Hydrophobic
Phe 13 cxb1.2 N-loop ILE 279 A VdWContact
Val 23 B1.2 B1 ILE 27 A Hydrophobic
His 25 B1.4 B1 ASP 30 A HBDonor
His 25 B1.4 B1 ASP 30 A VdWContact
His 25 B1.4 B1 VAL 28 A Hydrophobic
His 25 B1.4 B1 VAL 28 A VdWContact
Leu 26 B1.5 B1 VAL 29 A Hydrophobic
Leu 26 B1.5 B1 ILE 27 A Hydrophobic
Leu 26 B1.5 B1 ASP 30 A HBAcceptor
Leu 26 B1.5 B1 ASP 30 A VdWContact
Leu 26 B1.5 B1 VAL 28 A HBDonor
Leu 26 B1.5 B1 VAL 28 A VdWContact
Lys 27 B1.6 B1 ASP 30 A VdWContact
Lys 27 B1.6 B1 VAL 32 A Hydrophobic
Ile 28 B1.7 B1 ASP 30 A HBDonor
Ile 28 B1.7 B1 ASP 30 A VdWContact
Ile 28 B1.7 B1 VAL 32 A HBAcceptor
Ile 28 B1.7 B1 VAL 32 A VdWContact
Ile 28 B1.7 B1 VAL 29 A Hydrophobic
Ile 28 B1.7 B1 VAL 29 A VdWContact
Ile 28 B1.7 B1 THR 31 A Hydrophobic
Ile 28 B1.7 B1 THR 31 A VdWContact
Leu 29 b1b2.4 30s-loop PHE 285 A Hydrophobic
Leu 29 b1b2.4 30s-loop VAL 32 A Hydrophobic
Leu 29 b1b2.4 30s-loop VAL 32 A VdWContact
Asn 30 b1b2.7 30s-loop MET 33 A Hydrophobic
Asn 30 b1b2.7 30s-loop MET 33 A VdWContact
Asn 30 b1b2.7 30s-loop CYS 34 A HBAcceptor
Asn 30 b1b2.7 30s-loop CYS 34 A VdWContact
Asn 30 b1b2.7 30s-loop VAL 32 A HBDonor
Asn 30 b1b2.7 30s-loop VAL 32 A VdWContact
Val 39 B2.3 B2 HIS 281 A Hydrophobic
Arg 47 b2b3.12 40s-loop TYR 282 A CationPi
Arg 47 b2b3.12 40s-loop LEU 280 A HBDonor
Arg 47 b2b3.12 40s-loop LEU 280 A VdWContact
Arg 47 b2b3.12 40s-loop HIS 281 A VdWContact
Gln 48 B3.1 B3 HIS 281 A Hydrophobic
Gln 48 B3.1 B3 HIS 281 A VdWContact
Cys 50 B3.3 B3 HIS 281 A VdWContact
Tyr 61 H.6 Helix VAL 29 A Hydrophobic
Tyr 61 H.6 Helix ILE 27 A Hydrophobic
Tyr 61 H.6 Helix ILE 27 A HBDonor
Tyr 61 H.6 Helix ILE 27 A VdWContact
Leu 62 H.7 Helix VAL 29 A Hydrophobic
Ala 65 H.10 Helix VAL 29 A Hydrophobic
Ala 65 H.10 Helix VAL 29 A VdWContact
Leu 66 CT.1 C-term THR 31 A Hydrophobic
CHEMOKINE DIAGRAM
L N T P N C A L 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term Y R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K A L N K
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical