Interactions for 6LFO — Binding Partner: CXCR2

Structure details

PDB ID: 6LFO open_in_new
Protein: CXCL8_HUMAN
Organism: Homo sapiens
UniProt ID: P10145 open_in_new

Method: Cryo-em
Resolution: 3.4 Å
Date: Sept. 2, 2020
Reference: 10.1038/S41586-020-2492-5 open_in_new
State: Monomer

Chemokine Chain: D
Partner Chain: R

Download PDB

3D view

NGL viewer powered by MMTF.

Chemokine diagram

Interactions for this Binding Partner

Download list as CSV

Chemokine Residue	Generic Number	Segment	Partner Residue	Partner Chain	Interaction Type
Ala 2	NTc.Cm5	N-term	LYS 108	R	Hydrophobic
Ala 2	NTc.Cm5	N-term	LYS 108	R	VdWContact
Lys 3	NTc.Cm4	N-term	TYR 197	R	Hydrophobic
Lys 3	NTc.Cm4	N-term	TYR 197	R	VdWContact
Lys 3	NTc.Cm4	N-term	TRP 104	R	Hydrophobic
Glu 4	NTc.Cm3	N-term	ARG 278	R	HBAcceptor
Glu 4	NTc.Cm3	N-term	ARG 278	R	Anionic
Glu 4	NTc.Cm3	N-term	ARG 278	R	VdWContact
Glu 4	NTc.Cm3	N-term	TYR 197	R	VdWContact
Glu 4	NTc.Cm3	N-term	ARG 289	R	Anionic
Glu 4	NTc.Cm3	N-term	ARG 289	R	VdWContact
Glu 4	NTc.Cm3	N-term	LEU 296	R	Hydrophobic
Leu 5	NTc.Cm2	N-term	TYR 197	R	Hydrophobic
Leu 5	NTc.Cm2	N-term	TYR 197	R	VdWContact
Leu 5	NTc.Cm2	N-term	ARG 289	R	VdWContact
Arg 6	NTc.Cm1	N-term	ARG 289	R	Hydrophobic
Arg 6	NTc.Cm1	N-term	ARG 289	R	VdWContact
Gln 8	CX.4	CX	PRO 38	R	Hydrophobic
Gln 8	CX.4	CX	PRO 38	R	VdWContact
Lys 11	cxb1.2	N-loop	ALA 36	R	Hydrophobic
Lys 11	cxb1.2	N-loop	ALA 36	R	VdWContact
Lys 11	cxb1.2	N-loop	LEU 34	R	Hydrophobic
Tyr 13	cxb1.6	N-loop	LEU 34	R	Hydrophobic
Tyr 13	cxb1.6	N-loop	LEU 34	R	VdWContact
Lys 15	cxb1.8	N-loop	LEU 29	R	Hydrophobic
Lys 15	cxb1.8	N-loop	LEU 29	R	VdWContact
His 18	cxb1.14	N-loop	SER 27	R	VdWContact
His 18	cxb1.14	N-loop	THR 28	R	Hydrophobic
His 18	cxb1.14	N-loop	THR 28	R	VdWContact
Phe 21	B1.1	B1	PHE 32	R	Hydrophobic
Phe 21	B1.1	B1	PHE 32	R	VdWContact
Gly 31	b1b2.8	30s-loop	THR 204	R	HBAcceptor
Gly 31	b1b2.8	30s-loop	THR 204	R	VdWContact
Pro 32	b1b2.9	30s-loop	VAL 187	R	Hydrophobic
Pro 32	b1b2.9	30s-loop	THR 204	R	VdWContact
Asp 45	b2b3.4	40s-loop	PHE 32	R	VdWContact
Arg 47	b2b3.12	40s-loop	ASP 35	R	HBDonor
Arg 47	b2b3.12	40s-loop	ASP 35	R	Cationic
Arg 47	b2b3.12	40s-loop	ASP 35	R	VdWContact
Arg 47	b2b3.12	40s-loop	PHE 32	R	Hydrophobic
Arg 47	b2b3.12	40s-loop	PHE 32	R	HBDonor
Arg 47	b2b3.12	40s-loop	PHE 32	R	VdWContact
Glu 48	B3.1	B3	ALA 37	R	Hydrophobic
Glu 48	B3.1	B3	ALA 37	R	VdWContact
Leu 49	B3.2	B3	LEU 34	R	Hydrophobic

Interactions for 6LFO — Binding Partner: CXCR2

Structure details

3D view

Chemokine diagram

Interactions for this Binding Partner

Interaction pattern search