Interactions
8K3Z | CXCL12_HUMAN — CXCR4
Residue contacts: 55
SUMMARY
- Protein
- CXCL12_HUMAN View protein entry
- Organism
- Homo sapiens
- UniProt ID
- P48061 View on UniProt
- PDB ID
- 8K3Z View on PDB
- Method
- Cryo-em
- Resolution
- 2.81 Å
- Date
- July 17, 2024
- Reference
- -
- State
- Monomer
Chain information
- Chemokine chain
- D
- Partner chain
- A
3D VIEW
INTERACTION TABLE
Download CSV| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Lys 1 | NTc.Cm8 | N-term | HIS 113 | A | Hydrophobic |
| Lys 1 | NTc.Cm8 | N-term | CYS 186 | A | HBDonor |
| Lys 1 | NTc.Cm8 | N-term | CYS 186 | A | VdWContact |
| Lys 1 | NTc.Cm8 | N-term | ASP 187 | A | Cationic |
| Lys 1 | NTc.Cm8 | N-term | ASP 97 | A | Cationic |
| Lys 1 | NTc.Cm8 | N-term | TRP 94 | A | Hydrophobic |
| Lys 1 | NTc.Cm8 | N-term | TRP 94 | A | VdWContact |
| Pro 2 | NTc.Cm7 | N-term | TYR 116 | A | Hydrophobic |
| Pro 2 | NTc.Cm7 | N-term | PHE 292 | A | Hydrophobic |
| Pro 2 | NTc.Cm7 | N-term | TRP 94 | A | Hydrophobic |
| Pro 2 | NTc.Cm7 | N-term | GLU 288 | A | VdWContact |
| Val 3 | NTc.Cm6 | N-term | ILE 259 | A | Hydrophobic |
| Val 3 | NTc.Cm6 | N-term | ILE 259 | A | VdWContact |
| Val 3 | NTc.Cm6 | N-term | TYR 255 | A | Hydrophobic |
| Val 3 | NTc.Cm6 | N-term | ILE 284 | A | Hydrophobic |
| Val 3 | NTc.Cm6 | N-term | GLU 288 | A | HBDonor |
| Val 3 | NTc.Cm6 | N-term | GLU 288 | A | VdWContact |
| Ser 4 | NTc.Cm5 | N-term | HIS 281 | A | HBAcceptor |
| Ser 4 | NTc.Cm5 | N-term | HIS 281 | A | VdWContact |
| Ser 4 | NTc.Cm5 | N-term | GLU 288 | A | HBDonor |
| Ser 4 | NTc.Cm5 | N-term | GLU 288 | A | VdWContact |
| Leu 5 | NTc.Cm4 | N-term | LEU 41 | A | Hydrophobic |
| Leu 5 | NTc.Cm4 | N-term | ALA 98 | A | Hydrophobic |
| Leu 5 | NTc.Cm4 | N-term | ALA 98 | A | VdWContact |
| Leu 5 | NTc.Cm4 | N-term | TRP 94 | A | Hydrophobic |
| Tyr 7 | NTc.Cm2 | N-term | ASP 187 | A | HBDonor |
| Tyr 7 | NTc.Cm2 | N-term | ASP 187 | A | VdWContact |
| Arg 8 | NTc.Cm1 | N-term | ASP 262 | A | HBDonor |
| Arg 8 | NTc.Cm1 | N-term | ASP 262 | A | Cationic |
| Arg 8 | NTc.Cm1 | N-term | ASP 262 | A | VdWContact |
| Arg 8 | NTc.Cm1 | N-term | ARG 30 | A | VdWContact |
| Pro 10 | CX.4 | CX | CYS 28 | A | HBAcceptor |
| Pro 10 | CX.4 | CX | CYS 28 | A | VdWContact |
| Pro 10 | CX.4 | CX | PRO 27 | A | Hydrophobic |
| Pro 10 | CX.4 | CX | PRO 27 | A | VdWContact |
| Pro 10 | CX.4 | CX | PHE 29 | A | Hydrophobic |
| Phe 13 | cxb1.2 | N-loop | GLU 268 | A | Hydrophobic |
| Phe 13 | cxb1.2 | N-loop | GLU 268 | A | VdWContact |
| Phe 13 | cxb1.2 | N-loop | LYS 25 | A | VdWContact |
| Glu 15 | cxb1.6 | N-loop | LYS 25 | A | VdWContact |
| Leu 29 | b1b2.4 | 30s-loop | PHE 29 | A | Hydrophobic |
| Leu 29 | b1b2.4 | 30s-loop | PHE 29 | A | VdWContact |
| Pro 32 | b1b2.9 | 30s-loop | PHE 189 | A | Hydrophobic |
| Pro 32 | b1b2.9 | 30s-loop | SER 178 | A | HBAcceptor |
| Pro 32 | b1b2.9 | 30s-loop | SER 178 | A | VdWContact |
| Pro 32 | b1b2.9 | 30s-loop | ILE 185 | A | Hydrophobic |
| Asn 33 | b1b2.10 | 30s-loop | PHE 189 | A | Hydrophobic |
| Asn 33 | b1b2.10 | 30s-loop | PHE 189 | A | VdWContact |
| Val 39 | B2.3 | B2 | PHE 29 | A | Hydrophobic |
| Val 39 | B2.3 | B2 | PRO 27 | A | Hydrophobic |
| Val 39 | B2.3 | B2 | PRO 27 | A | VdWContact |
| Arg 47 | b2b3.12 | 40s-loop | GLU 26 | A | Hydrophobic |
| Gln 48 | B3.1 | B3 | PRO 27 | A | Hydrophobic |
| Gln 48 | B3.1 | B3 | PRO 27 | A | VdWContact |
| Val 49 | B3.2 | B3 | LYS 25 | A | VdWContact |
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