Interactions for 7VL9 — Binding Partner: CCR1
Structure details
- PDB ID: 7VL9 open_in_new
- Protein: CCL15_HUMAN
- Organism: Homo sapiens
- UniProt ID: Q16663 open_in_new
- Method: Cryo-em
- Resolution: 2.6 Å
- Date: March 23, 2022
- Reference: 10.1038/S41589-021-00918-Z open_in_new
- State: Monomer
- Chemokine Chain: L
- Partner Chain: R
Chemokine diagram
Interactions for this Binding Partner
Download list as CSV
| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Phe 26 | NTc.Cm6 | N-term | LYS 94 | R | VdWContact |
| Phe 26 | NTc.Cm6 | N-term | TYR 113 | R | Hydrophobic |
| Phe 26 | NTc.Cm6 | N-term | TYR 113 | R | VdWContact |
| Phe 26 | NTc.Cm6 | N-term | TYR 291 | R | Hydrophobic |
| Phe 26 | NTc.Cm6 | N-term | TYR 291 | R | VdWContact |
| Phe 26 | NTc.Cm6 | N-term | TRP 90 | R | Hydrophobic |
| Phe 26 | NTc.Cm6 | N-term | TRP 90 | R | PiStacking |
| Phe 26 | NTc.Cm6 | N-term | TYR 41 | R | Hydrophobic |
| Phe 26 | NTc.Cm6 | N-term | TYR 41 | R | VdWContact |
| Phe 26 | NTc.Cm6 | N-term | LEU 87 | R | Hydrophobic |
| His 27 | NTc.Cm5 | N-term | VAL 283 | R | Hydrophobic |
| His 27 | NTc.Cm5 | N-term | VAL 283 | R | VdWContact |
| His 27 | NTc.Cm5 | N-term | ASP 280 | R | Hydrophobic |
| Phe 28 | NTc.Cm4 | N-term | ARG 30 | R | VdWContact |
| Phe 28 | NTc.Cm4 | N-term | THR 182 | R | Hydrophobic |
| Phe 28 | NTc.Cm4 | N-term | TYR 93 | R | Hydrophobic |
| Phe 28 | NTc.Cm4 | N-term | TYR 93 | R | VdWContact |
| Phe 28 | NTc.Cm4 | N-term | ASP 97 | R | VdWContact |
| Ala 29 | NTc.Cm3 | N-term | ARG 30 | R | VdWContact |
| Ala 29 | NTc.Cm3 | N-term | ASP 280 | R | Hydrophobic |
| Ala 30 | NTc.Cm2 | N-term | ARG 30 | R | VdWContact |
| Asp 31 | NTc.Cm1 | N-term | ARG 30 | R | HBAcceptor |
| Asp 31 | NTc.Cm1 | N-term | ARG 30 | R | Anionic |
| Asp 31 | NTc.Cm1 | N-term | ARG 30 | R | VdWContact |
| Asp 31 | NTc.Cm1 | N-term | LYS 26 | R | HBAcceptor |
| Asp 31 | NTc.Cm1 | N-term | LYS 26 | R | VdWContact |
| Cys 32 | CX.1 | CX | PRO 23 | R | VdWContact |
| Thr 34 | cxb1.1 | N-loop | GLU 272 | R | Hydrophobic |
| Thr 34 | cxb1.1 | N-loop | CYS 273 | R | Hydrophobic |
| Thr 34 | cxb1.1 | N-loop | CYS 273 | R | VdWContact |
| Ser 35 | cxb1.2 | N-loop | ALA 21 | R | VdWContact |
| Ile 37 | cxb1.6 | N-loop | ALA 21 | R | Hydrophobic |
| Leu 45 | B1.1 | B1 | TYR 18 | R | Hydrophobic |
| Met 46 | B1.2 | B1 | TYR 18 | R | Hydrophobic |
| Met 46 | B1.2 | B1 | TYR 18 | R | VdWContact |
| Phe 50 | B1.6 | B1 | HIS 186 | R | Hydrophobic |
| Phe 50 | B1.6 | B1 | GLU 177 | R | Hydrophobic |
| Phe 50 | B1.6 | B1 | GLU 177 | R | VdWContact |
| Phe 50 | B1.6 | B1 | GLN 175 | R | Hydrophobic |
| Phe 50 | B1.6 | B1 | GLN 175 | R | VdWContact |
| Glu 51 | B1.7 | B1 | HIS 189 | R | Hydrophobic |
| Glu 51 | B1.7 | B1 | LYS 173 | R | Anionic |
| Glu 51 | B1.7 | B1 | HIS 186 | R | VdWContact |
| Glu 51 | B1.7 | B1 | GLN 175 | R | VdWContact |
| Ser 53 | b1b2.6 | 30s-loop | SER 184 | R | HBDonor |
| Ser 53 | b1b2.6 | 30s-loop | SER 184 | R | VdWContact |
| Ser 54 | b1b2.9 | 30s-loop | LYS 196 | R | HBAcceptor |
| Ser 54 | b1b2.9 | 30s-loop | LYS 196 | R | VdWContact |
| Ser 54 | b1b2.9 | 30s-loop | LEU 192 | R | VdWContact |
| Ser 54 | b1b2.9 | 30s-loop | PHE 187 | R | HBAcceptor |
| Ser 54 | b1b2.9 | 30s-loop | PHE 187 | R | VdWContact |
| Cys 56 | b1b2.12 | 30s-loop | LYS 196 | R | HBAcceptor |
| Cys 56 | b1b2.12 | 30s-loop | LYS 196 | R | VdWContact |
| Ser 57 | b1b2.13 | 30s-loop | ASP 266 | R | VdWContact |
| Ser 57 | b1b2.13 | 30s-loop | GLN 265 | R | VdWContact |
| Ser 57 | b1b2.13 | 30s-loop | ARG 193 | R | HBAcceptor |
| Ser 57 | b1b2.13 | 30s-loop | ARG 193 | R | VdWContact |
| Pro 59 | b1b2.16 | 30s-loop | LEU 192 | R | Hydrophobic |
| Pro 59 | b1b2.16 | 30s-loop | HIS 189 | R | Hydrophobic |
| Pro 59 | b1b2.16 | 30s-loop | HIS 189 | R | VdWContact |
| Ile 62 | B2.3 | B2 | PHE 178 | R | Hydrophobic |
| Ile 62 | B2.3 | B2 | PHE 178 | R | VdWContact |
| Ile 62 | B2.3 | B2 | PRO 23 | R | Hydrophobic |
| Leu 64 | B2.5 | B2 | PHE 178 | R | Hydrophobic |
| Leu 64 | B2.5 | B2 | PHE 178 | R | VdWContact |
| Thr 65 | B2.6 | B2 | TYR 18 | R | Hydrophobic |
| Thr 65 | B2.6 | B2 | TYR 18 | R | VdWContact |
| Lys 67 | b2b3.4 | 40s-loop | TYR 18 | R | Hydrophobic |
| Lys 67 | b2b3.4 | 40s-loop | TYR 18 | R | VdWContact |
| Arg 69 | b2b3.12 | 40s-loop | TYR 18 | R | CationPi |
| Arg 69 | b2b3.12 | 40s-loop | GLY 19 | R | VdWContact |
| Gln 70 | B3.1 | B3 | PRO 23 | R | Hydrophobic |
| Gln 70 | B3.1 | B3 | PRO 23 | R | VdWContact |
| Gln 70 | B3.1 | B3 | GLN 25 | R | HBAcceptor |
| Gln 70 | B3.1 | B3 | GLN 25 | R | VdWContact |
| Val 71 | B3.2 | B3 | TYR 18 | R | Hydrophobic |
| Val 71 | B3.2 | B3 | TYR 18 | R | VdWContact |
| Cys 72 | B3.3 | B3 | PRO 23 | R | VdWContact |
| Pro 75 | b3h.2 | 50s-loop | HIS 189 | R | Hydrophobic |
| Pro 75 | b3h.2 | 50s-loop | HIS 189 | R | VdWContact |
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