Interactions for 8IC0 — Binding Partner: CXCR1
Structure details
- PDB ID: 8IC0 open_in_new
- Protein: CXCL8_HUMAN
- Organism: Homo sapiens
- UniProt ID: P10145 open_in_new
- Method: Cryo-em
- Resolution: 3.41 Å
- Date: July 19, 2023
- Reference: 10.1038/S41467-023-39799-2 open_in_new
- State: Monomer
- Chemokine Chain: F
- Partner Chain: A
Chemokine diagram
Interactions for this Binding Partner
Download list as CSV
| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Ser 1 | NTc.Cm6 | N-term | SER 184 | A | VdWContact |
| Ala 2 | NTc.Cm5 | N-term | VAL 186 | A | VdWContact |
| Lys 3 | NTc.Cm4 | N-term | GLU 291 | A | Cationic |
| Glu 4 | NTc.Cm3 | N-term | ARG 199 | A | Anionic |
| Glu 4 | NTc.Cm3 | N-term | LEU 287 | A | Hydrophobic |
| Glu 4 | NTc.Cm3 | N-term | ARG 269 | A | HBAcceptor |
| Glu 4 | NTc.Cm3 | N-term | ARG 269 | A | Anionic |
| Glu 4 | NTc.Cm3 | N-term | ARG 269 | A | VdWContact |
| Glu 4 | NTc.Cm3 | N-term | ARG 203 | A | HBAcceptor |
| Glu 4 | NTc.Cm3 | N-term | ARG 203 | A | Anionic |
| Leu 5 | NTc.Cm2 | N-term | TYR 188 | A | Hydrophobic |
| Arg 6 | NTc.Cm1 | N-term | ASP 265 | A | HBDonor |
| Arg 6 | NTc.Cm1 | N-term | ASP 265 | A | Cationic |
| Arg 6 | NTc.Cm1 | N-term | ASP 265 | A | VdWContact |
| Arg 6 | NTc.Cm1 | N-term | ARG 269 | A | VdWContact |
| Arg 6 | NTc.Cm1 | N-term | ARG 280 | A | VdWContact |
| Gln 8 | CX.4 | CX | PRO 29 | A | Hydrophobic |
| Gln 8 | CX.4 | CX | PRO 29 | A | VdWContact |
| Cys 9 | CX.5 | CX | PRO 29 | A | Hydrophobic |
| Ile 10 | cxb1.1 | N-loop | GLU 275 | A | Hydrophobic |
| Lys 11 | cxb1.2 | N-loop | ASP 26 | A | HBDonor |
| Lys 11 | cxb1.2 | N-loop | ASP 26 | A | Cationic |
| Lys 11 | cxb1.2 | N-loop | ASP 26 | A | VdWContact |
| Lys 11 | cxb1.2 | N-loop | TYR 27 | A | VdWContact |
| Tyr 13 | cxb1.6 | N-loop | PRO 22 | A | Hydrophobic |
| Tyr 13 | cxb1.6 | N-loop | PRO 22 | A | VdWContact |
| Lys 15 | cxb1.8 | N-loop | PRO 21 | A | Cationic |
| Lys 15 | cxb1.8 | N-loop | PRO 21 | A | VdWContact |
| Lys 15 | cxb1.8 | N-loop | PRO 22 | A | VdWContact |
| Pro 32 | b1b2.9 | 30s-loop | THR 195 | A | Hydrophobic |
| Pro 32 | b1b2.9 | 30s-loop | THR 195 | A | HBAcceptor |
| Pro 32 | b1b2.9 | 30s-loop | THR 195 | A | VdWContact |
| Pro 32 | b1b2.9 | 30s-loop | TYR 178 | A | Hydrophobic |
| Pro 32 | b1b2.9 | 30s-loop | TYR 178 | A | VdWContact |
| Ile 40 | B2.3 | B2 | PRO 29 | A | Hydrophobic |
| Arg 47 | b2b3.12 | 40s-loop | PRO 22 | A | VdWContact |
| Arg 47 | b2b3.12 | 40s-loop | ALA 23 | A | VdWContact |
| Glu 48 | B3.1 | B3 | SER 28 | A | HBAcceptor |
| Glu 48 | B3.1 | B3 | SER 28 | A | VdWContact |
| Glu 48 | B3.1 | B3 | TYR 27 | A | VdWContact |
| Leu 49 | B3.2 | B3 | TYR 27 | A | Hydrophobic |
| Leu 49 | B3.2 | B3 | TYR 27 | A | VdWContact |
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