Interactions for 8U4O — Binding Partner: CXCR4


Structure details

  • Chemokine Chain: J
  • Partner Chain: R
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Chemokine diagram

L N T P N C A L 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term K P V S L S Y R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K A

Interactions for this Binding Partner

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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Lys 1 NTc.Cm8 N-term HIS 113 R Hydrophobic
Lys 1 NTc.Cm8 N-term HIS 113 R VdWContact
Lys 1 NTc.Cm8 N-term TRP 94 R Hydrophobic
Lys 1 NTc.Cm8 N-term ASP 97 R Cationic
Lys 1 NTc.Cm8 N-term ASP 187 R Hydrophobic
Lys 1 NTc.Cm8 N-term ASP 187 R VdWContact
Lys 1 NTc.Cm8 N-term CYS 186 R HBDonor
Lys 1 NTc.Cm8 N-term CYS 186 R VdWContact
Pro 2 NTc.Cm7 N-term PHE 292 R Hydrophobic
Pro 2 NTc.Cm7 N-term TRP 94 R Hydrophobic
Val 3 NTc.Cm6 N-term ILE 284 R Hydrophobic
Ser 4 NTc.Cm5 N-term SER 285 R VdWContact
Ser 4 NTc.Cm5 N-term GLU 288 R HBDonor
Ser 4 NTc.Cm5 N-term GLU 288 R VdWContact
Ser 4 NTc.Cm5 N-term HIS 281 R VdWContact
Leu 5 NTc.Cm4 N-term TRP 94 R Hydrophobic
Leu 5 NTc.Cm4 N-term LEU 41 R Hydrophobic
Leu 5 NTc.Cm4 N-term ALA 98 R Hydrophobic
Ser 6 NTc.Cm3 N-term ASP 187 R HBDonor
Ser 6 NTc.Cm3 N-term ASP 187 R VdWContact
Tyr 7 NTc.Cm2 N-term ASP 187 R Hydrophobic
Tyr 7 NTc.Cm2 N-term ASP 187 R HBDonor
Tyr 7 NTc.Cm2 N-term ASP 187 R VdWContact
Arg 8 NTc.Cm1 N-term LEU 266 R VdWContact
Arg 8 NTc.Cm1 N-term ASP 262 R Cationic
Pro 10 CX.4 CX PHE 29 R Hydrophobic
Cys 11 CX.5 CX PRO 27 R VdWContact
Arg 12 cxb1.1 N-loop ASP 193 R Cationic
Arg 12 cxb1.1 N-loop ASP 193 R VdWContact
Gln 48 B3.1 B3 GLU 26 R VdWContact
Val 49 B3.2 B3 PRO 27 R VdWContact

Interaction pattern search
(0.00 = no similarity, 1.00 = identical)