Interactions

1QG7 | CXCL12_HUMAN — CXCL12

Residue contacts: 63
SUMMARY
Protein
CXCL12_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P48061 View on UniProt
PDB ID
1QG7 View on PDB
Method
X-ray
Resolution
2.0 Å
Date
Feb. 28, 2001
Reference
10.1089/10799900050116390 Open DOI
State
Dimer
Chain information
Chemokine chain
A
Partner chain
B
3D VIEW
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Arg 20 cxb1.15 N-loop ASN 30 B HBDonor
Arg 20 cxb1.15 N-loop ASN 30 B VdWContact
Val 23 B1.2 B1 ASN 30 B HBAcceptor
Val 23 B1.2 B1 ASN 30 B VdWContact
Lys 24 B1.3 B1 ASN 30 B HBAcceptor
Lys 24 B1.3 B1 ASN 30 B VdWContact
His 25 B1.4 B1 LEU 29 B Hydrophobic
His 25 B1.4 B1 LYS 27 B Hydrophobic
His 25 B1.4 B1 LYS 27 B PiCation
Leu 26 B1.5 B1 ILE 28 B HBAcceptor
Leu 26 B1.5 B1 ILE 28 B HBDonor
Leu 26 B1.5 B1 ILE 28 B VdWContact
Leu 26 B1.5 B1 LYS 27 B VdWContact
Lys 27 B1.6 B1 LEU 26 B VdWContact
Lys 27 B1.6 B1 HIS 25 B Hydrophobic
Ile 28 B1.7 B1 LEU 62 B Hydrophobic
Ile 28 B1.7 B1 LEU 62 B VdWContact
Ile 28 B1.7 B1 TYR 61 B Hydrophobic
Ile 28 B1.7 B1 TYR 61 B HBAcceptor
Ile 28 B1.7 B1 TYR 61 B VdWContact
Ile 28 B1.7 B1 ILE 28 B Hydrophobic
Ile 28 B1.7 B1 HIS 25 B VdWContact
Ile 28 B1.7 B1 LEU 26 B HBAcceptor
Ile 28 B1.7 B1 LEU 26 B HBDonor
Ile 28 B1.7 B1 LEU 26 B VdWContact
Leu 29 b1b2.4 30s-loop TYR 61 B VdWContact
Leu 29 b1b2.4 30s-loop HIS 25 B Hydrophobic
Leu 29 b1b2.4 30s-loop HIS 25 B VdWContact
Asn 30 b1b2.7 30s-loop TYR 61 B Hydrophobic
Asn 30 b1b2.7 30s-loop TYR 61 B HBDonor
Asn 30 b1b2.7 30s-loop TYR 61 B VdWContact
Leu 36 b1b2.16 30s-loop GLU 63 B Hydrophobic
Leu 36 b1b2.16 30s-loop ALA 65 B Hydrophobic
Ile 38 B2.2 B2 ALA 65 B Hydrophobic
Ile 58 H.3 Helix ALA 65 B Hydrophobic
Gln 59 H.4 Helix ALA 65 B HBDonor
Gln 59 H.4 Helix ALA 65 B VdWContact
Gln 59 H.4 Helix LEU 66 B VdWContact
Tyr 61 H.6 Helix ASN 30 B Hydrophobic
Tyr 61 H.6 Helix ASN 30 B VdWContact
Tyr 61 H.6 Helix ILE 28 B Hydrophobic
Tyr 61 H.6 Helix ILE 28 B HBDonor
Tyr 61 H.6 Helix ILE 28 B VdWContact
Leu 62 H.7 Helix LEU 66 B Hydrophobic
Leu 62 H.7 Helix LEU 62 B Hydrophobic
Leu 62 H.7 Helix ILE 28 B Hydrophobic
Leu 62 H.7 Helix ILE 28 B VdWContact
Leu 62 H.7 Helix ALA 65 B Hydrophobic
Leu 62 H.7 Helix ALA 65 B VdWContact
Ala 65 H.10 Helix GLN 37 B Hydrophobic
Ala 65 H.10 Helix GLN 37 B VdWContact
Ala 65 H.10 Helix ILE 38 B Hydrophobic
Ala 65 H.10 Helix ILE 28 B Hydrophobic
Leu 66 CT.1 C-term LEU 66 B Hydrophobic
Leu 66 CT.1 C-term LEU 66 B VdWContact
Leu 66 CT.1 C-term LYS 54 B HBAcceptor
Leu 66 CT.1 C-term LYS 54 B VdWContact
Leu 66 CT.1 C-term ILE 58 B Hydrophobic
Leu 66 CT.1 C-term GLN 59 B Hydrophobic
Leu 66 CT.1 C-term LEU 62 B Hydrophobic
Leu 66 CT.1 C-term ILE 38 B Hydrophobic
Asn 67 CT.2 C-term LYS 54 B Anionic
Asn 67 CT.2 C-term LYS 54 B VdWContact
CHEMOKINE DIAGRAM
L N T P N C A L 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term S Y R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K A L N
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical